Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa†,Chemical Communications

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Desferrioxamine:gallium-pluronic micelles increase outer membrane permeability and potentiate antibiotic activity against Pseudomonas aeruginosa†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-11-08 00:00:00 , DOI: 10.1039/c8cc08134d
Max Purro ₁ , Jing Qiao , Zhi Liu , Morgan Ashcraft , May P Xiong

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The outer membrane of Pseudomonas aeruginosa functions primarily as a permeability barrier and imparts a broad spectrum of intrinsic antibiotic resistance. Herein, we describe the synthesis, characterization, and antimicrobial evaluation of a targeted polymeric micelle that specifically permeabilizes the outer membrane and potentiates antibiotic activity against P. aeruginosa.

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