Herein, we report the preparation of 1,2,4-thiadiazinane 1,1-dioxides from reaction of β-aminoethane sulfonamides with dichloromethane, dibromomethane and formaldehyde as methylene donors. The β-aminoethane sulfonamides were obtained through sequential Michael addition of amines to α,β-unsaturated ethenesulfonyl fluorides followed by further DBU mediated sulfur(VI) fluoride exchange (SuFEx) reaction with amines at the S–F bond.

中文翻译：

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通过三组分 SuFEx 型反应合成新型 1,2,4-噻二嗪烷 1,1-二氧化物†

在此，我们报道了由 β-氨基乙烷磺酰胺与二氯甲烷、二溴甲烷和甲醛作为亚甲基供体反应制备 1,2,4-噻二嗪烷 1,1-二氧化物。β-氨基乙烷磺酰胺是通过将胺连续迈克尔加成到 α,β-不饱和乙烯磺酰氟中，然后进一步 DBU 介导的硫 ( VI ) 氟化物交换 (SuFEx) 与胺在 S-F 键上的反应获得的。