Arylation Chemistry for Bioconjugation.,Angewandte Chemie International Edition

当前位置： X-MOL 学术 › Angew. Chem. Int. Ed. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Arylation Chemistry for Bioconjugation.
Angewandte Chemie International Edition ( IF 16.1 ) Pub Date : 2019-02-15 , DOI: 10.1002/anie.201806009
Chi Zhang ₁ , Ekaterina V Vinogradova _{1,

2} , Alexander M Spokoyny _{1,

3} , Stephen L Buchwald ₁ , Bradley L Pentelute ₁

Affiliation

Bioconjugation chemistry has been used to prepare modified biomolecules with functions beyond what nature intended. Central to these techniques is the development of highly efficient and selective bioconjugation reactions that operate under mild, biomolecule compatible conditions. Methods that form a nucleophile–sp² carbon bond show promise for creating bioconjugates with new modifications, sometimes resulting in molecules with unparalleled functions. Here we outline and review sulfur, nitrogen, selenium, oxygen, and carbon arylative bioconjugation strategies and their applications to modify peptides, proteins, sugars, and nucleic acids

中文翻译：

用于生物共轭的芳基化化学。

生物共轭化学已被用来制备具有超出自然预期功能的修饰生物分子。这些技术的核心是开发在温和、生物分子相容的条件下进行的高效和选择性生物共轭反应。形成亲核试剂-sp ²碳键的方法有望创建具有新修饰的生物缀合物，有时会产生具有无与伦比功能的分子。在这里，我们概述并回顾了硫、氮、硒、氧和碳芳基化生物共轭策略及其在修饰肽、蛋白质、糖和核酸方面的应用

更新日期：2019-02-15

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11