In Alzheimer's disease (AD), characterized by cognitive deterioration, synaptic alterations are frequently reported. The TgCRND8 model, in which mice develop AD-like amyloid β plaque formation, has been used to investigate the effects of amyloidosis on synaptic function. Background strain impacts the behavioral and neuropathological phenotype of mice in this model, but whether this extends to synaptic function is unknown. We investigated the influence of background strain on basal synaptic transmission and long-term potentiation (LTP) in the hippocampus of TgCRND8 mice (13–16 months) on hybrid backgrounds of (129SvEv/Tac) x (C3H/C57/129SvEv/Tac) (aka “129”) or (C57) x (C3H/C57) (aka “C3H”). In littermate controls, basal synaptic transmission was significantly reduced, whereas the amplitude of excitatory postsynaptic potentials was significantly higher after LTP induction in 129 vs. C3H mice. In 129 TgCRND8 mice, deficits in hippocampal LTP were more severe than in C3H TgCRND8 relative to controls. Compared to controls, network excitability was decreased in transgenics from both strains. These data suggest that 129 TgCRND8 mice are the more appropriate model to evaluate the efficacy of potential AD treatments on synaptic function, owing to their significant deficit in LTP. Such studies are critical in order to improve the translational capacity of basic science research.

在以认知能力下降为特征的阿尔茨海默氏病（AD）中，经常报告突触改变。TgCRND8模型用于研究淀粉样变性对突触功能的影响，在该模型中，小鼠会形成AD样淀粉样β斑块形成。在此模型中，背景应变会影响小鼠的行为和神经病理学表型，但尚不清楚该表型是否扩展到突触功能。我们在（129SvEv / Tac）x（C3H / C57 / 129SvEv / Tac）杂种背景下调查了背景菌株对TgCRND8小鼠（13–16个月）海马的基础突触传递和长期增强（LTP）的影响（又名“ 129”）或（C57）x（C3H / C57）（又名“ C3H”）。在同窝对照中，基础突触传递明显减少，LTP诱导后，与C3H小鼠相比，LTP诱导后兴奋性突触后电位的幅度明显更高（129）。在129只TgCRND8小鼠中，相对于对照组，海马LTP的缺陷比C3H TgCRND8的缺陷更为严重。与对照相比，两种菌株的转基因中的网络兴奋性均降低。这些数据表明，由于129种TgCRND8小鼠LTP明显不足，因此它们是评估潜在AD治疗对突触功能的功效的更合适模型。这些研究对于提高基础科学研究的翻译能力至关重要。两种菌株的转基因中的网络兴奋性均降低。这些数据表明，由于129 TgCRND8小鼠LTP明显不足，因此它们是评估潜在AD治疗对突触功能的功效的更合适模型。这些研究对于提高基础科学研究的翻译能力至关重要。两种菌株的转基因中的网络兴奋性均降低。这些数据表明，由于129 TgCRND8小鼠LTP明显不足，因此它们是评估潜在AD治疗对突触功能的功效的更合适模型。这些研究对于提高基础科学研究的翻译能力至关重要。