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The AbaR antibiotic resistance islands found in Acinetobacter baumannii global clone 1 – Structure, origin and evolution
Drug Resistance Updates ( IF 15.8 ) Pub Date : 2018-11-02 , DOI: 10.1016/j.drup.2018.10.003
Mohammad Hamidian , Ruth M. Hall

In multiply resistant Acinetobacter baumannii, complex transposons located in the chromosomal comM gene carry antibiotic and heavy metal resistance determinants. For one type, known collectively as AbaR, the ancestral form, AbaR0, entered a member of global clone 1 (GC1) in the mid 1970s and continued to evolve in situ forming many variants. In AbaR0, antibiotic and mercuric ion resistance genes are located between copies of a cadmium-zinc resistance transposon, Tn6018, and this composite transposon is in a class III transposon, Tn6019, carrying arsenate/arsenite resistance genes and five tni transposition genes. The antibiotic resistance genes in the AbaR0 and derived AbaR3 configurations are aphA1b, blaTEM, catA1, sul1, tetA(A), and cassette-associated aacC1 and aadA1 genes. These genes are in a specific arrangement of fragments from well-known transposons, e.g. Tn1, Tn1721, Tn1696 and Tn2670, that arose in an IncM1 plasmid. All known GC1 lineage 1 isolates carry AbaR0 or AbaR3, which arose around 1990, or a variant derived from one of them. Variants arose via deletions caused by one of three internal IS26s, by recombination between duplicate copies of sul1 or Tn6018, or by gene cassette addition or replacement. A few GC2 isolates also carry an AbaR island with different cassette-associated genes, aacA4 and oxa20.



中文翻译:

鲍曼不动杆菌全球克隆1中发现的AbaR抗生素抗性岛-结构,起源和进化

在多重耐药鲍曼不动杆菌中,位于染色体comM基因中的复杂转座子带有抗生素和重金属耐药性决定簇。对于一种统称为AbaR的类型,祖先形式AbaR0在1970年代中期进入全球克隆1(GC1)的成员,并继续原位进化形成许多变体。在AbaR0中,抗生素和汞离子抗性基因位于镉锌抗性转座子Tn 6018的副本之间而该复合转座子位于III类转座子Tn 6019中,携带砷酸/亚砷酸盐抗性基因和五个tni转座基因。AbaR0和衍生的AbaR3构型中的抗生素抗性基因是aphA1bbla TEMcatA1sul1,tetA(A)以及与盒相关的aacC1aadA1基因。这些基因是来自IncP1质粒中的著名转座子(例如Tn 1,Tn 1721, Tn 1696和Tn 2670)的片段的特定排列。所有已知的GC1谱系1分离株均带有AbaR0或AbaR3,它们起源于1990年左右,或衍生自其中之一。变体是由于三个内部IS 26之一引起的缺失而引起的例如,通过在sul1或Tn 6018的重复副本之间进行重组或通过添加或替换基因盒来实现。一些GC2分离株还带有一个AbaR岛,带有不同的盒相关基因aacA4oxa20

更新日期:2018-11-02
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