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Assisted reproduction in endometriosis
Best Practice & Research Clinical Endocrinology & Metabolism ( IF 6.1 ) Pub Date : 2018-11-03 , DOI: 10.1016/j.beem.2018.10.001
Dominique de Ziegler , Paul Pirtea , Marie Carbonnel , Marine Poulain , Ettore Cicinelli , Carlo Bulletti , Konstantinos Kostaras , George Kontopoulos , David Keefe , Jean Marc Ayoubi

Endometriosis – a disease causing pain and infertility – is encountered in nearly 50% of infertile women. While medical treatment is effective on pain and recurrence of symptoms after surgical excision, it is of no help for treating infertility for which the only options considered are surgery and ART.

Surgery enhances the chances of conceiving naturally during the 12–18 ensuing months irrespective of the stage of the disease. Surgery however is of no help when ART is considered, as it does not improve outcome and can only harm the ovarian response to stimulation. Today therefore, ART is commonly the primary option to be considered in women whose infertility is associated with endometriosis and whose ovarian reserve is compromised and/or who are over 35 years of age. When, ART is envisioned it is best to opt for a segmented ART approach with agonist trigger, freeze all and deferred embryo transfer.



中文翻译:

子宫内膜异位症的辅助生殖

子宫内膜异位症-一种引起疼痛和不育的疾病-在近50%的不育妇女中遇到。尽管药物治疗对手术切除后的疼痛和症状复发有效,但对于不育症,这是没有帮助的,考虑的唯一选择是手术和抗逆转录病毒疗法。

不管疾病的阶段如何,在接下来的12-18个月中,手术都会增加自然受孕的机会。然而,考虑抗逆转录病毒治疗时,手术无济于事,因为它不能改善预后,只会损害卵巢对刺激的反应。因此,今天,ART通常是不育症与子宫内膜异位症相关联且卵巢储备受到损害和/或年龄超过35岁的女性要考虑的主要选择。设想ART时,最好选择具有激动剂触发作用的分段ART方法,将其全部冷冻并推迟胚胎移植。

更新日期:2018-11-03
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