Mild dynamic kinetic resolution of amines by coupled visible-light photoredox and enzyme catalysis†,Chemical Communications

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Mild dynamic kinetic resolution of amines by coupled visible-light photoredox and enzyme catalysis†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-11-01 00:00:00 , DOI: 10.1039/c8cc07990k
Qiong Yang _{1,

2,

3,

4,

5} , Fengqian Zhao _{1,

2,

3,

4,

5} , Na Zhang _{1,

2,

3,

4,

5} , Mingke Liu _{1,

2,

3,

4,

5} , Huanhuan Hu _{1,

2,

3,

4,

5} , Jingjie Zhang _{1,

2,

3,

4,

5} , Shaolin Zhou _{1,

2,

3,

4,

5}

Affiliation

Herein, we described photoenzymatic dynamic kinetic resolution (DKR) of amines under mild conditions. The racemization of amines via a photoredox-mediated hydrogen atom transfer (HAT) protocol in conjunction with an enzyme catalyst to achieve the DKR of amines allows a variety of primary amines to be converted into a single enantiomer in high yield and with excellent enantioselectivity. Notably, this protocol can also be extended to 1,4-diamine derivatives with high levels of diastereo- and enantioselectivity.

中文翻译：

结合可见光光氧化还原和酶催化实现的胺的温和动态动力学拆分†

在这里，我们描述了在温和条件下胺的光酶动力学动力学拆分（DKR）。胺通过光氧化还原介导的氢原子转移（HAT）方案与酶催化剂的外消旋作用实现胺的DKR，可以将多种伯胺以高收率和出色的对映选择性转化为单一对映体。值得注意的是，该方案还可以扩展到具有高水平的非对映和对映选择性的1,4-二胺衍生物。

更新日期：2018-11-01

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