Transcriptomics in pain research: insights from new and old technologies,Molecular Omics

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Transcriptomics in pain research: insights from new and old technologies
Molecular Omics ( IF 3.0 ) Pub Date : 2018-10-30 , DOI: 10.1039/c8mo00181b
H. Starobova _{1,

2,

3,

4,

5} , Himaya S. W. A. _{1,

2,

3,

4,

5} , R. J. Lewis _{1,

2,

3,

4,

5} , I. Vetter _{1,

2,

3,

4,

5}

Affiliation

Despite significant advances in our understanding of the molecular basis of pain, the precise contributions of individual genes to our perception of this primal sensation remains incomplete. However, transcriptomic studies – providing a snapshot of the mRNA expression of a given cell or tissue – have considerably increased insight into the gene expression fingerprint of specific sensory neuronal subtypes, as well as gene expression changes that occur in diverse pathologies associated with pain. Moreover, transcriptomic studies have accelerated the identification of venom-derived peptides that may provide novel leads for the development of analgesics. This review discusses some of the key techniques, insights and limitations of transcriptomic studies that have contributed to pain research and highlights how the application of transcriptomics can be used to accelerate analgesic venom peptide drug discovery.

中文翻译：

疼痛研究中的转录组学：来自新旧技术的见解

尽管我们对疼痛的分子基础的理解有了长足的进步，但是单个基因对我们对这种原始感觉的感知的精确贡献仍然不完整。但是，转录组学研究（提供给定细胞或组织的mRNA表达的快照）大大提高了对特定感觉神经元亚型的基因表达指纹的了解，以及与疼痛相关的多种病理学中发生的基因表达变化。此外，转录组学研究加速了毒液衍生肽的鉴定，这可能为镇痛药的发展提供新的线索。这篇评论讨论了一些关键技术，

更新日期：2018-12-03

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