Propiconazole (PCZ) is an ergosterol biosynthesis inhibiting fungicide. Carvacrol (CAR) is a monoterpenoid phenol that has various beneficial health effects. The current research was designed to study the impact of PCZ on the behavior of rats and its ability to induce DNA damage in neurons as well as to clarify the ameliorative effect of CAR against these toxic impacts. Sixty Sprague-Dawley rats were randomly and equally divided into 4 experimental groups and treated daily by oral gavage for 2 months as follows: Group 1 (control); group 2 treated with PCZ (75 mg/kg); group 3 treated with CAR (50 mg/kg) and group 4 treated with both PCZ and CAR. Behavioral tests demonstrated that exposure to PCZ had a deleterious effect on psychological, motor and cognitive neural functions. Additionally, antioxidant enzyme activities, SOD and GSH-Px, were declined in brain tissue following exposure to PCZ. Moreover, comet assay revealed a high percent of DNA damage in the brain of rats exposed to PCZ. On the other hand, CAR administration ameliorated the harmful effects induced by PCZ through a protective mechanism that involved the improvement of neural functions and attenuation of oxidative stress and DNA damage.

丙哌唑（PCZ）是一种麦角固醇生物合成抑制性杀菌剂。香芹酚（CAR）是一种单萜类酚，具有多种有益健康的作用。当前的研究旨在研究PCZ对大鼠行为的影响及其诱导神经元DNA损伤的能力，并阐明CAR对抗这些毒性影响的改善作用。将60只Sprague-Dawley大鼠随机均分为4个实验组，每天通过管饲法治疗2个月，如下所示：第1组（对照组）；第2组（对照组）。用PCZ（75 mg / kg）治疗的第2组；第3组接受CAR（50 mg / kg）治疗，第4组接受PCZ和CAR治疗。行为测试表明，接触PCZ对心理，运动和认知神经功能具有有害作用。此外，抗氧化酶活性，SOD和GSH-Px，暴露于PCZ后脑组织中的维生素C含量下降。此外，彗星试验显示，暴露于PCZ的大鼠大脑中DNA损伤的百分比很高。另一方面，CAR管理通过保护机制改善了PCZ引起的有害影响，该保护机制涉及神经功能的改善以及氧化应激和DNA损伤的减轻。