We demonstrate that electrolyte-gated organic field-effect transistors (EGOFETs) can detect extremely minute modifications in the composition of the electrochemical double layers forming at the channel/electrolyte and gate/electrolyte interfaces, thus permitting real-time monitoring of alkylthiols self-assembling on a gold surface. We used this property to assay the enzymatic activity of acetylcholinesterase which, in the presence of its substrate (acetylthiocholine), produces thiocholine.

中文翻译：

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电解质门控有机场效应晶体管（EGOFET）作为电化学的补充工具用于表面过程的研究

我们证明，电解质门控有机场效应晶体管（EGOFET）可以检测在通道/电解质和栅极/电解质界面处形成的电化学双层的组成中的微小变化，从而可以实时监测烷基硫醇的自组装在金表面上。我们使用该性质来测定乙酰胆碱酯酶的酶促活性，该酶在其底物（乙酰基硫代胆碱）存在下会产生硫代胆碱。