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Advanced smart biomaterials and constructs for hard tissue engineering and regeneration.
Bone Research ( IF 14.3 ) Pub Date : 2018-10-22 , DOI: 10.1038/s41413-018-0032-9 Ke Zhang 1, 2 , Suping Wang 2, 3 , Chenchen Zhou 3 , Lei Cheng 2, 3 , Xianling Gao 2, 4 , Xianju Xie 1, 2 , Jirun Sun 5 , Haohao Wang 2, 3 , Michael D Weir 2 , Mark A Reynolds 2 , Ning Zhang 1, 2 , Yuxing Bai 1 , Hockin H K Xu 2, 6, 7
Bone Research ( IF 14.3 ) Pub Date : 2018-10-22 , DOI: 10.1038/s41413-018-0032-9 Ke Zhang 1, 2 , Suping Wang 2, 3 , Chenchen Zhou 3 , Lei Cheng 2, 3 , Xianling Gao 2, 4 , Xianju Xie 1, 2 , Jirun Sun 5 , Haohao Wang 2, 3 , Michael D Weir 2 , Mark A Reynolds 2 , Ning Zhang 1, 2 , Yuxing Bai 1 , Hockin H K Xu 2, 6, 7
Affiliation
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Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate minerals. Smart biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material's responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.
中文翻译：
用于硬组织工程和再生的先进智能生物材料和结构。
全球每年硬组织修复和再生花费数千亿美元，并且随着人口老龄化，需求大幅增加。硬组织包括含有磷酸钙矿物质的骨骼和牙齿结构。基于智能生物材料的组织工程和再生医学方法具有满足这一迫切需求的令人兴奋的潜力。智能生物材料和构建体是指通过设计材料对内部或外部刺激的响应能力，对细胞和组织具有指导/诱导或触发/刺激作用的生物材料和构建体，或者具有可以促进组织修复和再生的智能定制特性和功能。基于智能材料的方法包括用于骨组织工程的智能支架和干细胞构建体；智能药物输送系统可增强骨再生；智能牙科树脂可响应 pH 值以保护牙齿结构；智能pH敏感牙科材料，选择性抑制产酸细菌；智能聚合物可调节生物膜物种远离致病成分并转向健康成分；和智能材料来抑制生物膜并避免耐药性。这些智能生物材料不仅可以输送和引导干细胞改善组织再生，并在空间和暂时受控释放的情况下输送药物和生物活性剂，还可以调节/抑制生物膜并对抗伤口部位的感染。新一代智能生物材料提供了令人兴奋的潜力，并且是大幅增强硬组织工程和再生医学功效的有前途的机会。
更新日期：2019-11-18
中文翻译：
用于硬组织工程和再生的先进智能生物材料和结构。
全球每年硬组织修复和再生花费数千亿美元，并且随着人口老龄化，需求大幅增加。硬组织包括含有磷酸钙矿物质的骨骼和牙齿结构。基于智能生物材料的组织工程和再生医学方法具有满足这一迫切需求的令人兴奋的潜力。智能生物材料和构建体是指通过设计材料对内部或外部刺激的响应能力，对细胞和组织具有指导/诱导或触发/刺激作用的生物材料和构建体，或者具有可以促进组织修复和再生的智能定制特性和功能。基于智能材料的方法包括用于骨组织工程的智能支架和干细胞构建体；智能药物输送系统可增强骨再生；智能牙科树脂可响应 pH 值以保护牙齿结构；智能pH敏感牙科材料，选择性抑制产酸细菌；智能聚合物可调节生物膜物种远离致病成分并转向健康成分；和智能材料来抑制生物膜并避免耐药性。这些智能生物材料不仅可以输送和引导干细胞改善组织再生，并在空间和暂时受控释放的情况下输送药物和生物活性剂，还可以调节/抑制生物膜并对抗伤口部位的感染。新一代智能生物材料提供了令人兴奋的潜力，并且是大幅增强硬组织工程和再生医学功效的有前途的机会。
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