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Studies on relationships between essential and toxic elements in selected body fluids, cells and tissues
Chemico-Biological Interactions ( IF 5.1 ) Pub Date : 2018-10-21 , DOI: 10.1016/j.cbi.2018.10.011
Maria Długaszek

Processes occurring in the cellular and extracellular environment with the participation of elements both essential due to their vital functions and harmful to organism are complex and depend on many factors. The type of element and its chemical form as well as chemical composition of environment in which they occur play the significant role in the processes. But quantitative relationships between elements are also important, since both the excess and deficiency perturb their homeostasis in the organism. They can interact with each other at the absorption stage, transport in the blood, distribution in tissues and excretion. Quantitative correlations between Ca, Mg, Zn, Cu, Fe, Mn, Cr, Ni, Pb, Cd, and Al in some body fluids (serum, urine), cells (red blood cells) and tissues (human and animal hair, muscle and bone tissue, liver, kidney, stomach) are presented in the paper. It was stated that the following pairs of elements correlate most often: Ca-Mg, Mg-Zn, Cu-Zn, Fe-Cd, and Pb-Cd. It seems that the crucial role in the correlations between elements play their similarity in chemical and physical properties (first of all the size of ions radius and electric charge), the life processes in which the elements participate and the common environmental origin).



中文翻译:

研究所选体液,细胞和组织中必需和有毒元素之间的关系

在细胞和细胞外环境中发生的过程,由于其至关重要的功能而必不可少,并且对生物体有害,这些元素的参与是复杂的,并取决于许多因素。元素的类型及其化学形式以及它们所处的环境的化学组成在过程中起着重要作用。但是元素之间的定量关系也很重要,因为过量和不足都会扰乱它们在生物体内的动态平衡。它们可以在吸收阶段相互作用,在血液中运输,在组织中分布和排泄。某些体液(血清,尿液),细胞(红细胞)和组织(人和动物的毛发,肌肉)中的钙,镁,锌,铜,铁,锰,铬,镍,铅,镉和铝之间的定量相关性和骨骼组织,肝脏,肾脏,胃)在论文中提出。据指出,以下几对元素最相关:Ca-Mg,Mg-Zn,Cu-Zn,Fe-Cd和Pb-Cd。似乎在元素之间的相关性中的关键作用在化学和物理性质(首先是离子半径和电荷的大小),元素参与的生命过程以及共同的环境起源方面发挥着相似性。

更新日期:2018-10-21
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