Annual Review of Cell and Developmental Biology ( IF 11.4 ) Pub Date : 2018-10-08 00:00:00 , DOI: 10.1146/annurev-cellbio-100617-062932 Yukiko M. Yamashita 1 , Mayu Inaba 2 , Michael Buszczak 3
In recent years, thin membrane protrusions such as cytonemes and tunneling nanotubes have emerged as a novel mechanism of intercellular communication. Protrusion-based cellular interactions allow for specific communication between participating cells and have a distinct spectrum of advantages compared to secretion- and diffusion-based intercellular communication. Identification of protrusion-based signaling in diverse systems suggests that this mechanism is a ubiquitous and prevailing means of communication employed by many cell types. Moreover, accumulating evidence indicates that protrusion-based intercellular communication is often involved in pathogenesis, including cancers and infections. Here we review our current understanding of protrusion-based intercellular communication.
中文翻译:
通过细胞色素和纳米管的专门细胞间通讯
近年来,诸如细胞因子和隧穿纳米管的薄膜突起已经成为细胞间通讯的新机制。与基于分泌和扩散的细胞间通讯相比,基于突起的细胞相互作用可实现参与细胞之间的特定通讯,并具有独特的优势。在不同系统中基于突起的信号传导的鉴定表明,这种机制是许多细胞类型普遍使用的一种普遍的通信方式。此外,越来越多的证据表明,基于突起的细胞间通讯经常参与包括癌症和感染在内的发病机制。在这里,我们回顾我们目前对基于突起的细胞间通讯的理解。