Studies have highlighted the existence of two intra-pancreatic axes of communication: one involved in the regulation of enzyme production by insulin—the insular–acinar axis; and another involved in the regulation of insulin release by pancreatic enzymes—the acini–insular axis. Previous studies by our laboratory show that pancreatic enzymes can affect blood glucose homeostasis and insulin secretion independently of their digestive functions, both from the gut lumen and probably from the blood. As a result we would like to introduce here the concept of acini–islet–acinar (AIA) axis communication (feedback), which could play an important role in the development of obesity and diabetes type 2. The AIA feedback links the endocrine and exocrine parts of the pancreas and emphasizes the essential role that the pancreas plays, as a single organ, in the regulation of glucose homeostasis by amylase most probably in gut epithelium and by insulin and glucagon in peripheral blood.

研究表明，存在两个胰腺内沟通轴：一个涉及胰岛素对酶产生的调节-岛内-髋臼轴；另一个涉及胰岛内-交流轴。另一个涉及通过胰酶（acini-inular轴）调节胰岛素释放。我们实验室先前的研究表明，胰酶可以独立于消化功能（无论是来自肠腔还是可能来自血液）影响血糖稳态和胰岛素分泌。因此，我们想在此介绍acini-islet-acinar（AIA）轴交流（反馈）的概念，它可能在2型肥胖和糖尿病的发展中起重要作用。AIA反馈将内分泌和外分泌联系起来胰腺的各个部分，并强调胰腺作为单个器官发挥的重要作用，