BACKGROUND The use of effective cleaning/disinfectant products is important to control pathogens on healthcare surfaces. With the increasing number of wipe products available, there is a concern that combination of a formulation with the wrong material will decrease the efficacy of the product. This study aimed to use a range of efficacy test protocols to determine the efficacy of four formulations before and after binding to three commonly used wiping materials. METHODS Two quaternary ammonium (QAC)-based products, one hydrogen-peroxide-based product and one neutral cleaner were combined with microfibre, cotton or non-woven materials and tested for efficacy against Pseudomonas aeruginosa and Staphylococcus aureus with two surface tests (ASTM E2197-17 and EN13697-15) and two 'product' tests (ASTM E2967-15 and EN16615-15). FINDINGS Overall, the impact of using different materials on formulation efficacy was limited, except for an alkyl(C12-16)dimethylbenzylammonium chloride-based product used at 0.5% v/v. The hydrogen peroxide product was the most efficacious regardless of the material used. The results from wipe test ASTM E2967-15 were consistent with those from the surface tests, but not with EN16615-15 which was far less stringent. CONCLUSIONS The use of different wiping cloth materials may not impact severely on the efficacy of potent disinfectants, despite the absorption of different volumes of formulation by the materials. QAC-based formulations may be at higher risk when a low concentration is used. There were large differences in efficacy depending on the standard test performed, highlighting the need for more stringency in choosing the test to make a product claim on label.

中文翻译：

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测试规程和材料结合对抗菌擦拭巾功效的影响。

背景技术有效的清洁/消毒产品的使用对于控制保健表面上的病原体是重要的。随着可用擦拭产品数量的增加，人们担心配方与错误材料的组合会降低产品的功效。这项研究旨在使用一系列功效测试方案来确定四种制剂在与三种常用擦拭材料结合之前和之后的功效。方法将两种基于季铵盐（QAC）的产品，一种基于过氧化氢的产品和一种中性的清洁剂与微纤维，棉或非织造材料结合使用，并通过两项表面测试来测试其对铜绿假单胞菌和金黄色葡萄球菌的功效。 -17和EN13697-15）和两个“产品”测试（ASTM E2967-15和EN16615-15）。结果总的来说，除了以0.5％v / v使用的烷基（C12-16）二甲基苄基氯化铵基产品外，使用不同材料对制剂功效的影响是有限的。无论使用哪种材料，过氧化氢产品都是最有效的。擦拭测试ASTM E2967-15的结果与表面测试的结果一致，但EN16615-15的严格程度要低得多。结论尽管擦拭布材料吸收了不同体积的制剂，但使用不同的擦拭布材料可能不会严重影响强力消毒剂的功效。当使用低浓度时，基于QAC的制剂可能处于较高的风险中。根据所执行的标准测试，功效存在很大差异，