Isometric exercise training (IET)–induced reductions in resting blood pressure (RBP) have been achieved in laboratory environments, but data in support of IET outside the laboratory are scarce. The aim of this study was to compare 12 weeks of home-based (HOM) IET with laboratory-based, face-to-face (LAB) IET in hypertensive adults. Twenty-two hypertensive participants (24–60 years) were randomized to three conditions: HOM, LAB, or control (CON). IET involved isometric handgrip training (4 × 2 minutes at 30% maximum voluntary contraction, 3 days per week). RBP was measured every 6 weeks (0, 6, and 12 weeks) during training and 6 weeks after training (18 weeks). Clinically meaningful, but not statistically significant reductions in RBP were observed after 12 weeks of LAB IET (resting systolic blood pressure [SBP] −9.1 ± 4.1; resting diastolic blood pressure [DBP] −2.8 ± 2.1; P > .05), which was sustained for 6 weeks of detraining (SBP −8.2 ± 2.9; DBP −4 ± 2.9, P > .05). RBP was reduced in the HOM group after 12 weeks of training (SBP −9.7 ± 3.4; DBP −2.2 ± 2.0; P > .05), which was sustained for an additional 6 weeks of detraining (SBP −5.5 ± 3.4; DBP −4.6 ± 1.8; P > .05). Unsupervised home-based IET programs present an exciting opportunity for community-based strategies to combat hypertension, but additional work is needed if IET is to be used routinely outside the laboratory.

在实验室环境中，已经实现了等距运动训练（IET）引起的静息血压（RBP）降低，但缺乏实验室外支持IET的数据。这项研究的目的是比较高血压成年人中12周的家庭（HOM）IET与实验室的面对面（LAB）IET。22名高血压参与者（24-60岁）被随机分为以下三种情况：HOM，LAB或对照（CON）。IET参加了等距握力训练（4次×2分钟，最大自愿收缩率为30％，每周3天）。在训练期间和训练后每6周（18周）每6周（0、6和12周）测量RBP。LAB IET治疗12周后观察到RBP的临床意义下降，但无统计学意义（收缩压[SBP] -9.1±4.1；P  > .05），持续训练6周（SBP -8.2±2.9； DBP -4±2.9，P  > .05）。训练12周后HOM组的RBP降低（SBP -9.7±3.4; DBP -2.2±2.0; P  > .05），又持续了6周的减训练（SBP -5.5±3.4; DBP- 4.6±1.8；P  > .05）。无监督的家庭式IET计划为基于社区的抗击高血压策略提供了令人振奋的机会，但是如果要在实验室外常规使用IET，则需要额外的工作。