Development of novel strategies to overcome chemoresistance is central goal in ovarian cancer research. Natural history of the cancer development and progression is being reconstructed by genomic datasets to understand the evolutionary pattern and direction. Recent studies suggest that intra-tumor heterogeneity (ITH) is the main cause of treatment failure by chemoresistance in many types of cancers including ovarian cancer. ITH increases the fitness of tumor to adapt to incompatible microenvironment. Understanding ITH in relation to the evolutionary pattern may result in the development of the innovative approach based on individual variability in the genetic, environment, and life style. Thus, we can reach the new big stage conquering the cancer. In this review, we will discuss the recent advances in understanding ovarian cancer biology through the use of next generation sequencing (NGS) and highlight areas of recent progress to improve precision medicine in ovarian cancer.

研发克服化学耐药性的新策略是卵巢癌研究的主要目标。基因组数据集正在重建癌症发展和进展的自然史，以了解其进化模式和方向。最近的研究表明，在许多类型的癌症（包括卵巢癌）中，肿瘤内异质性（ITH）是化学抗性导致治疗失败的主要原因。ITH可提高肿瘤适应性，以适应不相容的微环境。了解有关进化模式的ITH可能会导致基于遗传，环境和生活方式的个体差异的创新方法的发展。这样，我们就可以进入征服癌症的新阶段。在这篇评论中，