Controlled ovarian hyperstimulation (COH) is a crucial part of assisted reproductive technologies (ART) that resulted in a substantial increase in pregnancy rates from in vitro fertilization (IVF). However, in spite of the apparent benefit of COH on an increase in the number of follicles and the number of oocytes retrieved, allowing for extended embryo culture and enabling the selection of the best quality embryo for transfer, several reports has shown that the supraphysiologic hormonal levels may indeed have a detrimental effect at the endometrial level. The current article revises the pathophysiological mechanisms through which ovarian stimulation may negatively affect endometrial receptivity. Also, the evidence is analyzed explaining how segmentation of IVF treatment may allow us to overcome the deleterious effects of hyperstimulation on endometrial receptivity. Deferred embryo transfer may be performed in a more physiologic uterine environment in a subsequent cycle, improve endometrial receptivity, decrease uterine contractility, diminishes the impact of premature luteinization and allow individualized stimulation according to the level of response.

受控卵巢过度刺激（COH）是辅助生殖技术（ART）的重要组成部分，该技术导致了体外受精（IVF）导致的妊娠率大大提高。然而，尽管COH在增加卵泡数量和回收卵母细胞数量方面具有明显的好处，可以延长胚胎培养时间，并能够选择最优质的胚胎进行移植，但一些报告显示，超生理激素的水平确实对子宫内膜有有害作用。当前文章修改了卵巢刺激可能对子宫内膜容受性产生负面影响的病理生理机制。还，分析了证据，解释了IVF治疗的细分如何使我们能够克服过度刺激对子宫内膜容受性的有害影响。延迟的胚胎移植可以在随后的周期中在更生理的子宫环境中进行，提高子宫内膜的接受度，降低子宫收缩力，减少过早黄体化的影响，并根据反应水平进行个体化刺激。