Abstract Gold nanoparticles with unique optical and photo-thermal properties have promising application in nanotheranostics, achieving the integration of diagnosis and therapy in a single platform. Compared with normal physiological environment, tumor tissue has a unique and complex tumor microenvironment, which plays a key role in tumor progression, metastasis, angiogenesis and even drug resistance. In recent years, many gold nanotheranostic platforms have been developed to target tumor microenvironment associated with acidic pH, hypoxia, angiogenesis, immune responses, pathological pressure gradients and extracellular matrix (ECM). In the present article, we have given special emphasis on key strategies for gold nanoparticles functionalization and highlighted recent advances in rational design of gold nanotheranostic platforms capable of utilizing, overcoming or modulating tumor microenvironment for effective cancer theranostics.

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用于靶向肿瘤微环境的刺激响应金纳米治疗平台

摘要 金纳米粒子具有独特的光学和光热特性，在纳米治疗学中具有广阔的应用前景，可在单一平台上实现诊断和治疗的一体化。与正常生理环境相比，肿瘤组织具有独特而复杂的肿瘤微环境，在肿瘤进展、转移、血管生成甚至耐药性中起着关键作用。近年来，已经开发了许多金纳米治疗平台，以靶向与酸性 pH、缺氧、血管生成、免疫反应、病理压力梯度和细胞外基质 (ECM) 相关的肿瘤微环境。在本文中，