The double lipoxygenation of polyunsaturated fatty acids (PUFA) is possible with PUFA having at least three methylene-interrupted double bonds. Several PUFA of the omega-3/n-3 and -6 families may be converted through this route, and the products show interesting inhibitory effects on blood platelet function and cyclooxygenase activities. This review focuses on two main omega-3 PUFA of nutritional interest, namely docosahexaenoic acid (DHA/22:6n-3) and alpha linolenic acid (ALA/18:3n-3). The chemical configuration of the double lipoxygenase end-product from DHA (protectin DX) is compared with that of protectin D1 which is produced through a mono-lipoxygenation step followed by an epoxidation and epoxide hydrolysis process. The different metabolic pathways are discussed as well as the different biological activities of both protectins.

多不饱和脂肪酸（PUFA）的双脂氧基化可以通过具有至少三个亚甲基间断双键的PUFA来实现。欧米伽3 / n-3和-6家族的几个PUFA可能会通过此途径转化，并且该产品对血小板功能和环氧合酶活性表现出有趣的抑制作用。这篇综述着重于两个主要的具有营养价值的omega-3 PUFA，即二十二碳六烯酸（DHA / 22：6n-3）和α亚麻酸（ALA / 18：3n-3）。将来自DHA（保护素DX）的双脂氧合酶终产物的化学构型与通过单脂氧合步骤，然后进行环氧化和环氧化物水解过程制得的保护素D1的化学构型进行了比较。讨论了两种保护素的不同代谢途径以及不同的生物学活性。