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Single-Cell (Multi)omics Technologies
Annual Review of Genomics and Human Genetics ( IF 7.7 ) Pub Date : 2018-08-31 00:00:00 , DOI: 10.1146/annurev-genom-091416-035324
Lia Chappell 1 , Andrew J.C. Russell 1 , Thierry Voet 1, 2
Affiliation  

Single-cell multiomics technologies typically measure multiple types of molecule from the same individual cell, enabling more profound biological insight than can be inferred by analyzing each molecular layer from separate cells. These single-cell multiomics technologies can reveal cellular heterogeneity at multiple molecular layers within a population of cells and reveal how this variation is coupled or uncoupled between the captured omic layers. The data sets generated by these techniques have the potential to enable a deeper understanding of the key biological processes and mechanisms driving cellular heterogeneity and how they are linked with normal development and aging as well as disease etiology. This review details both established and novel single-cell mono- and multiomics technologies and considers their limitations, applications, and likely future developments.

中文翻译:


单细胞(多)组学技术

单细胞多组学技术通常可以测量来自同一单个细胞的多种类型的分子,与通过分析来自不同细胞的每个分子层所得出的结论相比,它可以提供更深刻的生物学见解。这些单细胞多组学技术可以揭示一组细胞内多个分子层的细胞异质性,并揭示这种变化如何在捕获的渗透层之间耦合或不耦合。这些技术产生的数据集有可能使人们深入了解驱动细胞异质性的关键生物学过程和机制,以及它们与正常发育和衰老以及疾病病因学之间的联系。这篇评论详细介绍了既有的和新颖的单细胞单基因组和多组学技术,并考虑了它们的局限性,应用,

更新日期:2018-08-31
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