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Sclerotinia sclerotiorum: An Evaluation of Virulence Theories
Annual Review of Phytopathology ( IF 9.1 ) Pub Date : 2018-08-27 00:00:00 , DOI: 10.1146/annurev-phyto-080417-050052
Liangsheng Xu 1 , Guoqing Li 2, 3 , Daohong Jiang 2, 3 , Weidong Chen 4, 5
Affiliation  

Oxalic acid production in Sclerotinia sclerotiorum has long been associated with virulence. Research involving UV-induced, genetically undefined mutants that concomitantly lost oxalate accumulation, sclerotial formation, and pathogenicity supported the conclusion that oxalate is an essential pathogenicity determinant of S. sclerotiorum. However, recent investigations showed that genetically defined mutants that lost oxalic acid production but accumulated fumaric acid could cause disease on many plants and substantiated the conclusion that acidic pH, not oxalic acid per se, is the necessary condition for disease development. Critical evaluation of available evidence showed that the UV-induced mutants harbored previously unrecognized confounding genetic defects in saprophytic growth and pH responsiveness, warranting reevaluation of the conclusions about virulence based on the UV-induced mutants. Furthermore, analyses of the evidence suggested a hypothesis for the existence of an unrecognized regulator responsive to acidic pH. Identifying the unknown pH regulator would offer a new avenue for investigating pH sensing/regulation in S. sclerotiorum and novel targets for intervention in disease control strategies.

中文翻译:


核盘菌核盘菌:毒力理论的评价。

长期以来,核盘菌中草酸的产生一直与毒力有关。涉及紫外线诱导的,遗传上不确定的突变体同时丢失草酸盐积累,菌核形成和致病性的研究支持了以下结论:草酸盐是葡萄球菌的重要致病性决定因素。但是,最近的研究表明,遗传定义的突变体失去了草酸的生成而富集了富马酸,可能在许多植物上引起疾病,并证实了酸性pH值本身而不是草酸是疾病发展的必要条件的结论。对现有证据的严格评估表明,紫外线诱导的突变体在腐生菌生长和pH响应性方面具有以前无法识别的混杂遗传缺陷,因此有必要重新评估基于紫外线诱导的突变体的致病性结论。此外,对证据的分析提出了一个假设,即存在一个无法识别的对酸性pH作出反应的调节剂。鉴定未知的pH调节剂将为研究核盘菌中的pH感测/调节提供一条新途径 和干预疾病控制策略的新目标。

更新日期:2018-08-27
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