Polycystic ovary syndrome (PCOS) is a heterogeneous syndrome characterized by abnormal reproductive cycles, irregular ovulation, and hyperandrogenism. This complex disorder has its origins both within and outside the hypothalamic-pituitary-ovarian axis. Cardio-metabolic factors, such as obesity and insulin resistance, contribute to the manifestation of the PCOS phenotype. Polycystic ovary syndrome is one of the most common endocrine disorders among women of reproductive age. Growing evidence suggested an association between reproductive and metabolic features of PCOS and exposure to endocrine-disrupting chemicals (EDC), such as bisphenol A. Further, the environmental obesogen tributyltin (TBT) was shown to induce reproductive, metabolic and cardiovascular abnormalities resembling those found in women and animal models of PCOS. However, the causal link between TBT exposure and PCOS development remains unclear. The objective of this review was to summarize the most recent research findings on the potential association between TBT exposure and development of PCOS-like features in animal models and humans.

中文翻译：

---

肥胖三丁基锡可诱发多囊卵巢综合征（PCOS）的特征：综述

多囊卵巢综合症（PCOS）是一种异质综合症，其特征是生殖周期异常，排卵不规律和雄激素过多。这种复杂的疾病起源于下丘脑-垂体-卵巢轴内外。心血管代谢因素，例如肥胖和胰岛素抵抗，有助于PCOS表型的表现。多囊卵巢综合征是育龄妇女中最常见的内分泌疾病之一。越来越多的证据表明PCOS的生殖和代谢特征与暴露于内分泌干扰化学物质（EDC）（例如双酚A）之间存在关联。此外，已证明环境肥胖三丁基锡（TBT）会诱导生殖，代谢和心血管异常，与所发现的异常相似。在PCOS的妇女和动物模型中。然而，TBT暴露与PCOS发展之间的因果关系仍不清楚。这篇综述的目的是总结关于TBT暴露与动物模型和人类PCOS样特征的发展之间潜在关联的最新研究结果。