MicroRNA regulation of natural killer cell development and function in leukemia.,Molecular Immunology

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MicroRNA regulation of natural killer cell development and function in leukemia.
Molecular Immunology ( IF 3.2 ) Pub Date : 2018-08-09 , DOI: 10.1016/j.molimm.2018.07.022
Jennifer N Saultz ₁ , Aharon G Freud ₂ , Bethany L Mundy-Bosse ₃

Affiliation

MicroRNAs (miRNAs) are now recognized as important regulators of all cellular processes, including immune function and cancer survival. These evolutionary preserved, single-stranded, non-coding RNA molecules mediate important functional effects primarily through post-transcriptional regulation of protein expression. MiRNAs are known to mediate multiple oncogenic pathways in tumor cells, both tumor promoting and tumor suppressing. In addition to a direct tumor cell effect, miRNAs have also been shown to play a critical role in immune cell development, function and survival. Here we expand on previous reports to evaluate miRNA regulation in natural killer (NK) cells primarily in humans and focus on their influence on NK cell development and function in the setting of hematologic malignancies. In addition, we highlight the most recent miRNA discoveries in hematologic malignancies and discuss areas of future exploration relevant to the translational field of innate immunology and miRNA-based therapeutic intervention.

中文翻译：

MicroRNA 对白血病自然杀伤细胞发育和功能的调节。

MicroRNA (miRNA) 现在被认为是所有细胞过程的重要调节因子，包括免疫功能和癌症生存。这些进化保留的单链非编码 RNA 分子主要通过蛋白质表达的转录后调节来介导重要的功能效应。已知 miRNA 可介导肿瘤细胞中的多种致癌途径，包括促进肿瘤和抑制肿瘤。除了直接的肿瘤细胞作用外，miRNA 还被证明在免疫细胞的发育、功能和存活中发挥着关键作用。在这里，我们扩展了之前的报告，以评估主要在人类自然杀伤 (NK) 细胞中的 miRNA 调节，并重点关注它们对血液恶性肿瘤中 NK 细胞发育和功能的影响。此外，我们重点介绍了血液系统恶性肿瘤中最新的 miRNA 发现，并讨论了与先天免疫学和基于 miRNA 的治疗干预的转化领域相关的未来探索领域。

更新日期：2018-08-09

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