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Advances in nanoparticle and microparticle delivery systems for increasing the dispersibility, stability, and bioactivity of phytochemicals.
Biotechnology Advances ( IF 12.1 ) Pub Date : 2018-08-04 , DOI: 10.1016/j.biotechadv.2018.08.004
David Julian McClements 1
Affiliation  

Application of bioactive phytochemicals in foods, supplements, and pharmaceuticals is often limited because of their poor solubility, stability, and bioavailability. Phytochemical oral delivery systems (PODS), consisting of phytochemical-loaded nanoparticles or microparticles, can overcome these challenges. PODS can be produced in liquid, gel, paste, or solid forms. They must be carefully formulated to be compatible with the product matrix, economical, robust, and maintain phytochemical bioactivity. This review evaluates recent advances in the development of PODS, including microemulsions, nanoemulsions, emulsions, solid lipid nanoparticles, liposomes, and biopolymer microgels. Properly designed PODS will increase phytochemical applications in commercial products.



中文翻译:

纳米和微粒输送系统在提高植物化学物质的分散性,稳定性和生物活性方面取得了进展。

由于其溶解性,稳定性和生物利用度较差,在食品,补品和药品中生物活性植物化学物的应用通常受到限制。由载有植物化学物质的纳米颗粒或微粒组成的植物化学口服传递系统(PODS)可以克服这些挑战。PODS可以液体,凝胶,糊状或固体形式生产。它们必须经过精心配制,以与产品基质相容,经济,坚固并保持植物化学生物活性。这篇评论评估了PODS开发中的最新进展,包括微乳,纳米乳,乳剂,固体脂质纳米颗粒,脂质体和生物聚合物微凝胶。正确设计的PODS将增加植物化学产品在商业产品中的应用。

更新日期:2018-08-04
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