Teratogen screening with human pluripotent stem cells,Integrative Biology

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Teratogen screening with human pluripotent stem cells
Integrative Biology ( IF 1.5 ) Pub Date : 2018-08-10 , DOI: 10.1039/c8ib00082d
Kathryn E Worley ₁ , Jennifer Rico-Varela , Dominic Ho , Leo Q Wan

Affiliation

Birth defects are a common occurrence in the United States and worldwide. Currently, evaluation of potential developmental toxicants (i.e., teratogens) relies heavily on animal-based models which do not always adequately mimic human development. In order to address this, researchers are developing in vitro human-based models which utilize human pluripotent stem cells (hPSCs) to assess the teratogenic potential of chemical substances. The field of human developmental toxicity assays includes a variety of platforms including monolayer, micropattern, embryoid body, and 3D organoid cultures. In this review, we will overview the field of human teratogenic assays, detail the most recent advances, and discuss current limitations and future perspectives.

中文翻译：

人类多能干细胞致畸剂筛查

出生缺陷在美国和世界各地都很常见。目前，对潜在发育毒物（即致畸剂）的评估严重依赖于动物模型，该模型并不总是充分模拟人类发育。为了解决这个问题，研究人员正在开发体外人体模型，利用人类多能干细胞（hPSC）来评估化学物质的致畸潜力。人类发育毒性测定领域包括各种平台，包括单层、微图案、胚状体和 3D 类器官培养物。在这篇综述中，我们将概述人类致畸检测领域，详细介绍最新进展，并讨论当前的局限性和未来的前景。

更新日期：2018-08-10

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