Nutraceuticals in prostate cancer therapeutic strategies and their neo-adjuvant use in diverse populations.,npj Precision Oncology

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Nutraceuticals in prostate cancer therapeutic strategies and their neo-adjuvant use in diverse populations.
npj Precision Oncology ( IF 6.8 ) Pub Date : 2018-07-25 , DOI: 10.1038/s41698-018-0058-x
Dominique Reed ₁ , Komal Raina _{1,

2} , Rajesh Agarwal _{1,

2}

Affiliation

Prostate cancer (PCa) is the most frequently diagnosed malignancy and second leading cause of cancer mortality in American males. Notably, men of African descent in the United States and Caribbean have the highest PCa mortality rates compared to men with European ancestry. Although current therapeutics are quite potent and effective, disease resistance, progression to metastasis, therapy-associated toxicities and efficacy-related issues in diverse populations develop over time. Thus, non-toxic and efficacious therapeutic strategies are needed to address these major obstacles for the clinical treatment and management of PCa. In this regard, preclinical and population-based efficacy studies have shown the potential of natural non-toxic nutraceuticals as potent anti-PCa agents. Accordingly, the implementation of nutraceutical intervention and genetic testing in diverse populations might aid in the development and design of precision medicine strategies to reduce the burden of chemotherapy-associated toxicities, suppress disease resistance, and treat both localized and advanced PCa. Consequently, additional large-scale and inclusive clinical studies are required to fully assess efficacy and therapeutic limitations of these agents in PCa. This review discusses the most current clinical research on selected nutraceutical agents and their efficacy in the context of clinico-pathological outcomes and disease susceptibility in diverse PCa clinical and epidemiological studies.

中文翻译：

前列腺癌治疗策略中的营养保健品及其在不同人群中的新辅助用途。

前列腺癌 (PCa) 是美国男性最常诊断的恶性肿瘤，也是导致美国男性癌症死亡的第二大原因。值得注意的是，与欧洲血统男性相比，美国和加勒比地区的非洲裔男性前列腺癌死亡率最高。尽管目前的治疗方法相当有效，但随着时间的推移，不同人群中的疾病抵抗力、转移进展、治疗相关毒性和疗效相关问题都会出现。因此，需要无毒且有效的治疗策略来解决前列腺癌临床治疗和管理的这些主要障碍。在这方面，临床前和基于人群的功效研究表明天然无毒营养保健品作为有效的抗 PCa 药物的潜力。因此，在不同人群中实施营养干预和基因检测可能有助于精准医疗策略的开发和设计，以减轻化疗相关毒性的负担，抑制疾病抵抗力，并治疗局部和晚期前列腺癌。因此，需要进行额外的大规模和包容性临床研究来全面评估这些药物在前列腺癌中的疗效和治疗局限性。这篇综述讨论了所选营养药物的最新临床研究及其在不同 PCa 临床和流行病学研究中的临床病理结果和疾病易感性背景下的功效。

更新日期：2019-11-18

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