An essential element of tissue homeostasis is the response to injuries, cutaneous wound healing being the most studied example. In the adults, wound healing aims at quickly restoring the barrier function of the skin, leading however to scar, a dysfunctional fibrotic tissue. On the other hand, in fetuses a scarless tissue regeneration takes place. During ageing, the wound healing capacity declines; however, in the absence of comorbidities a higher quality in tissue repair is observed. Senescent cells have been found to accumulate in chronic unhealed wounds, but more recent reports indicate that their transient presence may be beneficial for tissue repair. In this review data on skin wound healing and scarring are presented, covering the whole spectrum from early embryonic development to adulthood, and furthermore until ageing of the organism.

中文翻译：

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无痕的伤口愈合：从发育到衰老。

组织稳态的基本要素是对损伤的反应，其中皮肤伤口愈合是研究最多的例子。在成年人中，伤口愈合的目的是迅速恢复皮肤的屏障功能，但导致瘢痕，即功能失调的纤维化组织。另一方面，在胎儿中发生了无疤痕的组织再生。在老化过程中，伤口的愈合能力下降。但是，在没有合并症的情况下，组织修复的质量更高。已经发现衰老细胞在慢性未愈合的伤口中积累，但是最近的报道表明它们的短暂存在可能对组织修复有益。在这篇综述中，提出了有关皮肤伤口愈合和瘢痕形成的数据，涵盖了从早期胚胎发育到成年，以及直至该生物体衰老的整个过程。