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Immediate Versus Deferred Switching From a Boosted Protease Inhibitor–based Regimen to a Dolutegravir-based Regimen in Virologically Suppressed Patients With High Cardiovascular Risk or Age ≥50 Years: Final 96-Week Results of the NEAT022 Study
Clinical Infectious Diseases ( IF 8.2 ) Pub Date : 2018-06-14 , DOI: 10.1093/cid/ciy505
José M Gatell 1 , Lambert Assoumou 2 , Graeme Moyle 3 , Laura Waters 4 , Margaret Johnson 5 , Pere Domingo 6 , Julie Fox 7 , Esteban Martinez 1 , Hans-Jürgen Stellbrink 8 , Giovanni Guaraldi 9 , Mar Masia 10 , Mark Gompels 11 , Stephane De Wit 12 , Eric Florence 13 , Stefan Esser 14 , François Raffi 15 , Christoph Stephan 16 , Juergen Rockstroh 17 , Andrea Giacomelli 18 , Jaime Vera 19 , José Ignacio Bernardino 20 , Alan Winston 21 , Maria Saumoy 22 , Julien Gras 23 , Christine Katlama 24 , Anton L Pozniak 3 , Linos Vandekerckhove , Els Caluwé , Stephane De Wit , Coca Necsoi , Eric Florence , Maartje Van Frankenhuijsen , Francois Raffi , Clotilde Allavena , Véronique Reliquet , Morane Cavellec , Audrey Rodallec , Thierry Le Tourneau , Jérôme Connault , Jean-Michel Molina , Samuel Ferret , Miresta Previlon , Yazdan Yazdanpanah , Roland Landman , Véronique Joly , Adriana Pinto Martinez , Christine Katlama , Fabienne Caby , Nadine Ktorza , Luminita Schneider , Christoph Stephan , Timo Wolf , Gundolf Schüttfort , Juergen Rockstroh , Jan-Christian Wasmuth , Carolynne Schwarze-Zander , Christoph Boesecke , Hans-Jurgen Stellbrink , Christian Hoffmann , Michael Sabranski , Stephan Esser , Robert Jablonka , Heidi Wiehler , Georg Behrens , Matthias Stoll , Gerrit Ahrenstorf , Giovanni Guaraldi , Giulia Nardini , Barbara Beghetto , Antonella D’Arminio Montforte , Teresa Bini , Viola Cogliandro , Massimo Di Pietro , Francesco Maria Fusco , Massimo Galli , Stefano Rusconi , Andrea Giacomelli , Paola Meraviglia , Esteban Martinez , Ana González-Cordón , Berta Torres , Pere Domingo , Gracia Mateo , Mar Gutierrez , Joaquin Portillo , Esperanza Merino , Sergio Reus , Vicente Boix , Mar Masia , Félix Gutiérrez , Sergio Padilla , Bonaventura Clotet , Eugenia Negredo , Anna Bonjoch , José L Casado , Sara Bañón-Escandell , Jose Saban , Africa Duque , Daniel Podzamczer , Maria Saumoy , Laura Acerete , Juan Gonzalez-Garcia , José Ignacio Bernardino , José Ramón Arribas , Victor Hontañón; , Graeme Moyle , Nicole Pagani , Margherita Bracchi , Jaime Vera , Amanda Clarke , Tanya Adams , Celia Richardson , Alan Winston , Borja Mora-Peris , Scott Mullaney , Laura Waters , Nahum de Esteban , Ana Milinkovic , Sarah Pett , Julie Fox , Juan Manuel Tiraboschi , Margaret Johnson , Mike Youle , Chloe Orkin , Simon Rackstraw , James Hand , Mark Gompels , Louise Jennings , Jane Nicholls , Sarah Johnston ,
Affiliation  

Both immediate and deferred switching from a ritonavir-boosted protease inhibitor (PI/r)–based regimen to a dolutegravir (DTG)–based regimen may improve lipid profile.

中文翻译:

在心血管病风险高或年龄≥50岁的患者中,立即从延缓蛋白酶抑制剂方案转为基于Dolutegravir方案的延期转换:NEAT022研究的最终96周结果

从基于利托那韦增强的蛋白酶抑制剂(PI / r)的方案到基于多卢格韦(DTG)的方案的立即和延后转换都可以改善脂质状况。
更新日期:2018-06-14
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