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DNA Nanotechnology-Enabled Interfacial Engineering for Biosensor Development
Annual Review of Analytical Chemistry ( IF 5.9 ) Pub Date : 2018-06-12 00:00:00 , DOI: 10.1146/annurev-anchem-061417-010007
Dekai Ye 1, 2 , Xiaolei Zuo 1, 3 , Chunhai Fan 1
Affiliation  

Biosensors represent biomimetic analytical tools for addressing increasing needs in medical diagnosis, environmental monitoring, security, and biodefense. Nevertheless, widespread real-world applications of biosensors remain challenging due to limitations of performance, including sensitivity, specificity, speed, and reproducibility. In this review, we present a DNA nanotechnology-enabled interfacial engineering approach for improving the performance of biosensors. We first introduce the main challenges of the biosensing interfaces, especially under the context of controlling the DNA interfacial assembly. We then summarize recent progress in DNA nanotechnology and efforts to harness DNA nanostructures to engineer various biological interfaces, with a particular focus on the use of framework nucleic acids. We also discuss the implementation of biosensors to detect physiologically relevant nucleic acids, proteins, small molecules, ions, and other biomarkers. This review highlights promising applications of DNA nanotechnology in interfacial engineering for biosensors and related areas.

中文翻译:


利用DNA纳米技术进行的界面工程技术,用于生物传感器的开发

生物传感器代表仿生分析工具,可满足医疗诊断,环境监测,安全性和生物防御方面日益增长的需求。然而,由于性能的限制,包括灵敏度,特异性,速度和可再现性,生物传感器在现实世界中的广泛应用仍然具有挑战性。在这篇综述中,我们提出了一种利用DNA纳米技术的界面工程方法来改善生物传感器的性能。我们首先介绍生物传感界面的主要挑战,尤其是在控制DNA界面组装的背景下。然后,我们总结了DNA纳米技术的最新进展以及利用DNA纳米结构工程化各种生物界面的努力,特别着重于框架核酸的使用。我们还将讨论生物传感器的实现,以检测生理相关的核酸,蛋白质,小分子,离子和其他生物标记。这篇综述重点介绍了DNA纳米技术在生物传感器及相关领域的界面工程中的有希望的应用。

更新日期:2018-06-12
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