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Engineering the Mucus Barrier
Annual Review of Biomedical Engineering ( IF 12.8 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1146/annurev-bioeng-062117-121156
T.L. Carlson 1 , J.Y. Lock 2 , R.L. Carrier 1, 2
Affiliation  

Mucus selectively controls the transport of molecules, particulate matter, and microorganisms to the underlying epithelial layer. It may be desirable to weaken the mucus barrier to enable effective delivery of drug carriers. Alternatively, the mucus barrier can be strengthened to prevent epithelial interaction with pathogenic microbes or other exogenous materials. The dynamic mucus layer can undergo changes in structure (e.g., pore size) and/or composition (e.g., protein concentrations, mucin glycosylation) in response to stimuli that occur naturally or are purposely administered, thus altering its barrier function. This review outlines mechanisms by which mucus provides a selective barrier and methods to engineer the mucus layer from the perspective of strengthening or weakening its barrier properties. In addition, we discuss strategic design of drug carriers and dosing formulation properties for efficient delivery across the mucus barrier.

中文翻译:


工程粘液屏障

粘液选择性地控制分子,微粒物质和微生物向下面的上皮层的运输。可能希望削弱粘液屏障以使药物载体有效递送。或者,可以增强粘液屏障以防止与病原微生物或其他外源性物质的上皮相互作用。动态粘液层可响应于自然发生或有意给予的刺激而经历结构(例如,孔径)和/或组成(例如,蛋白质浓度,粘蛋白糖基化)的变化,从而改变其屏障功能。这篇综述从增强或减弱其屏障特性的角度概述了粘液提供选择性屏障的机制和工程化粘液层的方法。此外,

更新日期:2018-06-04
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