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Platelet Mechanotransduction
Annual Review of Biomedical Engineering ( IF 12.8 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1146/annurev-bioeng-062117-121215
Caroline E. Hansen 1, 2 , Yongzhi Qiu 1, 2 , Owen J.T. McCarty 3, 4 , Wilbur A. Lam 1, 2
Affiliation  

The vasculature is a dynamic environment in which blood platelets constantly survey the endothelium for sites of vessel damage. The formation of a mechanically coherent hemostatic plug to prevent blood loss relies on a coordinated series of ligand–receptor interactions governing the recruitment, activation, and aggregation of platelets. The physical biology of each step is distinct in that the recruitment of platelets depends on the mechanosensing of the platelet receptor glycoprotein Ib for the adhesive protein von Willebrand factor, whereas platelet activation and aggregation are responsive to the mechanical forces sensed at adhesive junctions between platelets and at the platelet–matrix interface. Herein we take a biophysical perspective to discuss the current understanding of platelet mechanotransduction as well as the measurement techniques used to quantify the physical biology of platelets in the context of thrombus formation under flow.

中文翻译:


血小板机械转导

脉管系统是动态环境,在该环境中,血小板不断检查内皮是否有血管受损部位。为了防止失血,形成机械上相干的止血塞的过程依赖于一系列协调的配体-受体相互作用,从而控制血小板的募集,活化和聚集。每个步骤的物理生物学特点都不同,血小板的募集取决于血小板受体糖蛋白Ib对粘附蛋白von Willebrand因子的机械传感,而血小板的活化和聚集对在血小板与血管之间的粘附连接处感测到的机械力有反应。在血小板-基质界面。

更新日期:2018-06-04
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