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Structural DNA Nanotechnology: Artificial Nanostructures for Biomedical Research
Annual Review of Biomedical Engineering ( IF 12.8 ) Pub Date : 2018-06-04 00:00:00 , DOI: 10.1146/annurev-bioeng-062117-120904
Yonggang Ke 1 , Carlos Castro 2 , Jong Hyun Choi 3
Affiliation  

Structural DNA nanotechnology utilizes synthetic or biologic DNA as designer molecules for the self-assembly of artificial nanostructures. The field is founded upon the specific interactions between DNA molecules, known as Watson–Crick base pairing. After decades of active pursuit, DNA has demonstrated unprecedented versatility in constructing artificial nanostructures with significant complexity and programmability. The nanostructures could be either static, with well-controlled physicochemical properties, or dynamic, with the ability to reconfigure upon external stimuli. Researchers have devoted considerable effort to exploring the usability of DNA nanostructures in biomedical research. We review the basic design methods for fabricating both static and dynamic DNA nanostructures, along with their biomedical applications in fields such as biosensing, bioimaging, and drug delivery.

中文翻译:


结构DNA纳米技术:用于生物医学研究的人工纳米结构

结构性DNA纳米技术利用合成的或生物的DNA作为设计分子,以实现人工纳米结构的自组装。该领域建立在DNA分子之间的特定相互作用基础上,称为Watson-Crick碱基配对。经过数十年的积极追求,DNA在构造具有显着复杂性和可编程性的人造纳米结构中已显示出前所未有的多功能性。纳米结构可以是具有良好控制的物理化学性质的静态结构,也可以是动态的,具有在外部刺激下重新配置的能力。研究人员已投入大量精力来探索生物医学研究中DNA纳米结构的可用性。我们回顾了制造静态和动态DNA纳米结构的基本设计方法,

更新日期:2018-06-04
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