A randomised controlled trial to evaluate the plaque removal efficacy of sodium bicarbonate dentifrices in a single brushing clinical model,BDJ Open

当前位置： X-MOL 学术 › BDJ Open › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A randomised controlled trial to evaluate the plaque removal efficacy of sodium bicarbonate dentifrices in a single brushing clinical model
BDJ Open ( IF 2.5 ) Pub Date : 2018-06-04 , DOI: 10.1038/s41405-018-0003-7
Mary-Lynn Bosma ₁ , Kimberly R Milleman ₂ , Ivy Akwagyiram ₁ , Darren Targett ₁ , Jeffery L Milleman ₂

Affiliation

Objective

To evaluate plaque removal efficacy of dentifrices containing sodium bicarbonate (NaHCO₃) compared with a non-NaHCO₃ dentifrice after a single-timed brushing.

Materials and methods

A randomised, controlled, examiner-blinded, four-period, crossover study in 56 adults with a mean whole-mouth plaque index of ≥2.00 (six site modification of Turesky modification of Quigley-Hein Plaque Index [TPI]). Subjects brushed once for one timed minute with a 67% NaHCO₃ dentifrice with herbs; a 67% NaHCO₃ dentifrice without herbs; a 62% NaHCO₃ dentifrice with herbs; or a non-NaHCO₃ dentifrice without herbs. All contained 923 p.p.m. fluoride as sodium fluoride. Pre- and post-brushing plaque assessments were performed.

Results

Mean TPI score decreased from pre- to post-brushing with all treatments. There were statistically significantly greater reductions in plaque for NaHCO₃ dentifrices compared to non-NaHCO₃ (p < 0.0001 for all) with no significant differences between NaHCO₃-containing dentifrices. A post hoc analysis of plaque removal from different oral areas showed statistically significant differences in favour of the NaHCO₃ dentifrices over the non-NaHCO₃ dentifrice for almost all surfaces. No adverse events were reported.

Discussion and conclusion

Plaque removal was significantly greater with NaHCO₃-containing dentifrices compared with a non-NaHCO₃ dentifrice after a single, timed brushing. There was no effect of herbal tinctures. This study was registered at ClincalTrials.org: NCT03285984.

中文翻译：

评估碳酸氢钠牙膏在单次刷牙临床模型中去除牙菌斑功效的随机对照试验

客观的

旨在评估单次刷牙后含碳酸氢钠 (NaHCO ₃ ) 牙膏与不含 NaHCO ₃牙膏的牙菌斑去除效果。

材料和方法

一项随机、对照、检查者盲法、四阶段、交叉研究，对象为 56 名平均全口牙菌斑指数≥2.00 的成年人（Quigley-Hein 牙菌斑指数 [TPI] 的 Turesky 修正的六位点修正）。受试者使用含有草药的 67% NaHCO ₃牙膏刷牙一次，持续一分钟；不含草药的 67% NaHCO ₃牙膏； 62% NaHCO ₃草药牙膏；或不含草药的非 NaHCO ₃牙膏。所有产品均含有 923 ppm 氟化物（以氟化钠计）。进行刷牙前和刷牙后牙菌斑评估。

结果

所有治疗的平均 TPI 评分从刷牙前到刷牙后均有所下降。与非NaHCO ₃洁牙剂相比，NaHCO ₃洁牙剂的牙菌斑减少具有统计学意义（所有p <0.0001），而含NaHCO ₃洁牙剂之间没有显着差异。对不同口腔区域牙菌斑去除情况的事后分析显示，在几乎所有表面上，NaHCO ₃牙膏优于非 NaHCO ₃牙膏的统计学显着差异。没有不良事件的报告。