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Biomarkers Associated with Progression of Diabetic Kidney Disease: Do They Hold the Same Meaning for Blacks and Women?
Journal of the American Society of Nephrology ( IF 10.3 ) Pub Date : 2018-06-01 , DOI: 10.1681/asn.2017121249 LaTonya J. Hickson 1 , Joyce E. Balls-Berry 2 , Allan S. Jaffe 3 , Andrew D. Rule 1
Journal of the American Society of Nephrology ( IF 10.3 ) Pub Date : 2018-06-01 , DOI: 10.1681/asn.2017121249 LaTonya J. Hickson 1 , Joyce E. Balls-Berry 2 , Allan S. Jaffe 3 , Andrew D. Rule 1
Affiliation
We read with interest the study by Coca et al.,1 which examined the association of plasma TNF receptor-1 (TNFR-1), TNFR-2, and kidney injury molecule-1 (KIM-1) on renal outcomes in patients with type 2 diabetes mellitus. These investigations were performed on plasma samples from two previously conducted clinical trials involving patients with incident and progressive diabetic kidney disease (DKD) (n=1636). The findings support prior studies. In 2012, Niewczas et al.2 connected circulating markers of the proinflammatory cytokine (TNF-α) and the TNF pathway to the inflammatory state in DKD as a potential biomarker of DKD progression. These novel investigations (n=410) revealed the predictive capacity of plasma TNFR-1 and TNFR-2 in determining future DKD ESRD events. Since then, these studies have been replicated in predominantly white cohorts, with a few in other racial groups including American Indians and Chinese. One study by Chode et al.3 involved blacks (n=359), but it did not determine renal outcomes.
更新日期：2018-06-01
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