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Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis
Annual Review of Biophysics ( IF 10.4 ) Pub Date : 2018-05-24 00:00:00 , DOI: 10.1146/annurev-biophys-062215-010954
Adam James Waite 1, 2 , Nicholas W. Frankel 1, 3 , Thierry Emonet 1, 4
Affiliation  

Living cells detect and process external signals using signaling pathways that are affected by random fluctuations. These variations cause the behavior of individual cells to fluctuate over time (behavioral variability) and generate phenotypic differences between genetically identical individuals (phenotypic diversity). These two noise sources reduce our ability to predict biological behavior because they diversify cellular responses to identical signals. Here, we review recent experimental and theoretical advances in understanding the mechanistic origin and functional consequences of such variation in Escherichia coli chemotaxis—a well-understood model of signal transduction and behavior. After briefly summarizing the architecture and logic of the chemotaxis system, we discuss determinants of behavior and chemotactic performance of individual cells. Then, we review how cell-to-cell differences in protein abundance map onto differences in individual chemotactic abilities and how phenotypic variability affects the performance of the population. We conclude with open questions to be addressed by future research.

中文翻译:


细菌趋化性的行为变异性和表型多样性

活细胞使用受随机波动影响的信号通路检测和处理外部信号。这些变异会导致单个细胞的行为随时间波动(行为变异性),并在遗传相同的个体之间产生表型差异(表型多样性)。这两种噪声源降低了我们预测生物学行为的能力,因为它们使细胞对相同信号的反应多样化。在这里,我们回顾了最近的实验和理论进展,以了解这种变异在大肠杆菌中的机制起源和功能后果。化学趋化性-信号转导和行为的一个易于理解的模型。在简要总结了趋化性系统的体系结构和逻辑之后,我们讨论了单个细胞的行为和趋化性能的决定因素。然后,我们回顾了蛋白质丰度的细胞间差异如何映射到个体趋化能力的差异以及表型变异如何影响种群的表现。我们以开放的问题作为结束,以待将来的研究解决。

更新日期:2018-05-24
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