The pathophysiological mechanism of freezing of gait (FoG) has been linked to executive dysfunction. Cognitive training (CT) is a non-pharmacological intervention which has been shown to improve executive functioning in Parkinson’s disease (PD). This study aimed to explore whether targeted CT can reduce the severity of FoG in PD. Patients with PD who self-reported FoG and were free from dementia were randomly allocated to receive either a CT intervention or an active control. Both groups were clinician-facilitated and conducted twice-weekly for seven weeks. The primary outcome was percentage of time spent frozen during a Timed Up and Go task, assessed both on and off dopaminergic medications. Secondary outcomes included multiple neuropsychological and psychosocial measures. A full analysis was first conducted on all participants randomized, followed by a sample of interest including only those who had objective FoG at baseline, and completed the intervention. Sixty-five patients were randomized into the study. The sample of interest included 20 in the CT group and 18 in the active control group. The primary outcome of percentage time spent frozen during a gait task was significantly improved in the CT group compared to active controls in the on-state. There were no differences in the off-state. Patients who received CT also demonstrated improved processing speed and reduced daytime sleepiness compared to those in the active control. The findings suggest that CT can reduce the severity of FoG in the on-state, however replication in a larger sample is required.

步态冻结（FoG）的病理生理机制与执行功能障碍有关。认知训练（CT）是一种非药物干预措施，已被证明可以改善帕金森氏病（PD）的执行功能。这项研究旨在探讨靶向CT是否可以降低PD中FoG的严重程度。自我报告FoG且无痴呆的PD患者被随机分配接受CT干预或主动控制。两组均由临床医生主持，每周两次，共7周。主要结局是在定时和连续任务中冷冻所花费的时间百分比，评估多巴胺能药物的开和关。次要结果包括多种神经心理学和社会心理测量。首先对所有随机分组的参与者进行了全面分析，其次是感兴趣的样本，仅包括那些基线时具有客观FoG并完成干预的患者。65名患者被随机分为研究对象。感兴趣的样本包括CT组中的20个和活动对照组中的18个。与处于活动状态的主动对照组相比，CT组在步态任务中冻结所花费的时间百分比的主要结果得到了显着改善。断开状态没有差异。与主动对照组相比，接受CT的患者还显示出改善的处理速度和减少的白天嗜睡。研究结果表明，CT可以降低打开状态下FoG的严重性，但是需要在更大的样本中进行复制。65名患者被随机分为研究对象。感兴趣的样本包括CT组中的20个和活动对照组中的18个。与处于活动状态的主动对照组相比，CT组在步态任务中冻结所花费的时间所占百分比的主要结果得到了显着改善。断开状态没有差异。与主动对照组相比，接受CT的患者还显示出改善的处理速度和减少的白天嗜睡。研究结果表明，CT可以降低打开状态下FoG的严重性，但是需要在更大的样本中进行复制。65名患者被随机分为研究对象。感兴趣的样本包括CT组中的20个和活动对照组中的18个。与处于活动状态的主动对照组相比，CT组在步态任务中冻结所花费的时间所占百分比的主要结果得到了显着改善。断开状态没有差异。与主动对照组相比，接受CT的患者还显示出改善的处理速度和减少的白天嗜睡。研究结果表明，CT可以降低打开状态下FoG的严重性，但是需要在更大的样本中进行复制。与处于活动状态的主动对照组相比，CT组在步态任务中冻结所花费的时间所占百分比的主要结果得到了显着改善。断开状态没有差异。与主动对照组相比，接受CT的患者还显示出改善的处理速度和减少的白天嗜睡。研究结果表明，CT可以降低打开状态下FoG的严重性，但是需要在更大的样本中进行复制。与处于活动状态的主动对照组相比，CT组在步态任务中冻结所花费的时间所占百分比的主要结果得到了显着改善。断开状态没有差异。与主动对照组相比，接受CT的患者还显示出改善的处理速度和减少的白天嗜睡。研究结果表明，CT可以降低打开状态下FoG的严重性，但是需要在更大的样本中进行复制。