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Gd-DTPA-coupled Ag2Se quantum dots for dual-modality magnetic resonance imaging and fluorescence imaging in the second near-infrared window†
Nanoscale ( IF 5.8 ) Pub Date : 2018-05-15 00:00:00 , DOI: 10.1039/c8nr02017e Jiao-Jiao Ma 1, 2, 3, 4, 5 , Ming-Xia Yu 6, 7, 8, 9 , Zheng Zhang 6, 7, 8, 9 , Wei-Guo Cai 7, 8, 9, 10 , Zhi-Ling Zhang 1, 2, 3, 4, 5 , Hui-Li Zhu 1, 2, 3, 4, 5 , Qing-Yuan Cheng 6, 7, 8, 9 , Zhi-Quan Tian 1, 2, 3, 4, 5 , Dai-Wen Pang 1, 2, 3, 4, 5
Nanoscale ( IF 5.8 ) Pub Date : 2018-05-15 00:00:00 , DOI: 10.1039/c8nr02017e Jiao-Jiao Ma 1, 2, 3, 4, 5 , Ming-Xia Yu 6, 7, 8, 9 , Zheng Zhang 6, 7, 8, 9 , Wei-Guo Cai 7, 8, 9, 10 , Zhi-Ling Zhang 1, 2, 3, 4, 5 , Hui-Li Zhu 1, 2, 3, 4, 5 , Qing-Yuan Cheng 6, 7, 8, 9 , Zhi-Quan Tian 1, 2, 3, 4, 5 , Dai-Wen Pang 1, 2, 3, 4, 5
Affiliation
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Near-infrared (NIR) fluorescent quantum dots (QDs) are ideal platforms to fabricate multifunctional contrast agents for multimodal imaging. Herein, second near-infrared window fluorescent (NIR-II) Ag2Se QDs were coupled with gadopentetate dimeglumine injection (Gd-DTPA) for dual-modality T1-weighted magnetic resonance (MR) imaging and fluorescence imaging. In vitro experiments suggested that the prepared Ag2Se-Gd QDs exhibit low cytotoxicity, remarkable T1-weighted MR imaging, and fluorescence imaging contrast properties. In vivo experiment results showed that Ag2Se-Gd QDs were the preferred contrast agents for dual-modality T1-weighted MR imaging and fluorescence imaging with high spatial resolution. Moreover, excellent temporal resolution and high tissue penetration depth were also achieved by fluorescence imaging. These results indicate the potential of Ag2Se-Gd QDs as multifunctional contrast agents for multimodal imaging in clinical diagnosis and research.
中文翻译：
Gd-DTPA耦合的Ag 2 Se量子点，用于在第二个近红外窗口中进行双模态磁共振成像和荧光成像†
近红外（NIR）荧光量子点（QD）是制造用于多峰成像的多功能造影剂的理想平台。在此，第二次近红外窗口荧光（NIR-II）Ag 2 Se量子点与g戊二酸二聚葡胺注射液（Gd-DTPA）耦合，用于双模态T 1加权磁共振（MR）成像和荧光成像。体外实验表明，制备的Ag 2 Se-Gd QDs具有较低的细胞毒性，显着的T 1加权MR成像和荧光成像对比特性。体内实验结果表明，Ag 2 Se-Gd QD是双模态的首选造影剂T 1加权MR成像和具有高空间分辨率的荧光成像。此外，还通过荧光成像获得了出色的时间分辨率和较高的组织穿透深度。这些结果表明，Ag 2 Se-Gd QDs可以作为多功能造影剂用于临床诊断和研究中的多峰成像。
更新日期：2018-05-15
中文翻译：
Gd-DTPA耦合的Ag 2 Se量子点，用于在第二个近红外窗口中进行双模态磁共振成像和荧光成像†
近红外（NIR）荧光量子点（QD）是制造用于多峰成像的多功能造影剂的理想平台。在此，第二次近红外窗口荧光（NIR-II）Ag 2 Se量子点与g戊二酸二聚葡胺注射液（Gd-DTPA）耦合，用于双模态T 1加权磁共振（MR）成像和荧光成像。体外实验表明，制备的Ag 2 Se-Gd QDs具有较低的细胞毒性，显着的T 1加权MR成像和荧光成像对比特性。体内实验结果表明，Ag 2 Se-Gd QD是双模态的首选造影剂T 1加权MR成像和具有高空间分辨率的荧光成像。此外，还通过荧光成像获得了出色的时间分辨率和较高的组织穿透深度。这些结果表明，Ag 2 Se-Gd QDs可以作为多功能造影剂用于临床诊断和研究中的多峰成像。
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