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Viewpoint and practical recommendations from a movement disorder specialist panel on objective measurement in the clinical management of Parkinson’s disease
npj Parkinson's Disease ( IF 9.304 ) Pub Date : 2018-05-10 , DOI: 10.1038/s41531-018-0051-7
Per Odin , K. Ray Chaudhuri , Jens Volkmann , Angelo Antonini , Alexander Storch , Espen Dietrichs , Zvezdan Pirtošek , Tove Henriksen , Malcolm Horne , David Devos , Filip Bergquist

Motor aspects of Parkinson’s disease, such as fluctuations and dyskinesia, can be reliably evaluated using a variety of “wearable” technologies, but practical guidance on objective measurement (OM) and the optimum use of these devices is lacking. Therefore, as a first step, a panel of movement disorder specialists met to provide guidance on how OM could be assessed and incorporated into clinical guidelines. A key aspect of the incorporation of OM into the management of Parkinson’s disease (PD) is defining cutoff values that separate “controlled” from “uncontrolled” symptoms that can be modified by therapy and that relate to an outcome that is relevant to the person with PD (such as quality of life). Defining cutoffs by consensus, which can be subsequently tested and refined, is the first step to optimizing OM in the management of PD. OM should be used by all clinicians that treat people with PD but the least experienced may find the most value, but this requires guidance from experts to allow non-experts to apply guidelines. While evidence is gained for devices that produce OM, expert opinion is needed to supplement the evidence base.



中文翻译:

运动障碍专家小组关于帕金森氏病临床管理中客观测量的观点和实用建议

帕金森氏病的运动方面,例如波动和运动障碍,可以使用各种“可穿戴”技术可靠地进行评估,但缺乏客观测量(OM)的实用指南以及这些设备的最佳使用方法。因此,作为第一步,运动障碍专家小组举行会议,就如何评估OM并将其纳入临床指南提供指导。将OM纳入帕金森氏病(PD)管理的一个关键方面是定义临界值,该临界值将“可控”症状与“非可控”症状分开,这些症状可通过治疗加以改变,并与与患者相关的结局相关PD(例如生活质量)。通过共识定义临界值,可以随后进行测试和完善,这是在PD管理中优化OM的第一步。所有治疗PD的临床医生均应使用OM,但经验最少的患者可能会发现最大的价值,但这需要专家的指导,以允许非专家应用指南。在获得生产OM的设备的证据的同时,需要专家的意见来补充证据基础。

更新日期:2019-11-18
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