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Antisocial Personality as a Neurodevelopmental Disorder
Annual Review of Clinical Psychology ( IF 17.8 ) Pub Date : 2018-05-07 00:00:00 , DOI: 10.1146/annurev-clinpsy-050817-084819
Adrian Raine 1
Affiliation  

Although antisocial personality disorder (APD) is one of the most researched personality disorders, it is still surprisingly resistant to treatment. This lack of clinical progress may be partly due to the failure to view APD as a neurodevelopmental disorder and to consider early interventions. After first defining what constitutes a neurodevelopmental disorder, this review evaluates the extent to which APD meets neurodevelopmental criteria, covering structural and functional brain imaging, neurocognition, genetics and epigenetics, neurochemistry, and early health risk factors. Prevention and intervention strategies for APD are then outlined, focusing on addressing early biological and health systems, followed by forensic and clinical implications. It is argued both that APD meets criteria for consideration as a neurodevelopmental disorder and that consideration should be given both to the possibility that early onset conduct disorder is neurodevelopmental in nature, and also to the inclusion of psychopathy as a specifier in future Diagnostic and Statistical Manual revisions of APD.

中文翻译:


反社会人格作为神经发育障碍

尽管反社会人格障碍(APD)是研究最多的人格障碍之一,但它仍然令人惊讶地对治疗产生抵抗力。缺乏临床进展的部分原因可能是由于未能将APD视为神经发育障碍并没有考虑早期干预。在首先确定什么构成神经发育障碍后,本评价评估APD满足神经发育标准的程度,涵盖结构和功能性脑成像,神经认知,遗传学和表观遗传学,神经化学和早期健康危险因素。然后概述了APD的预防和干预策略,重点是解决早期的生物学和卫生系统,然后是法医和临床方面的问题。APD诊断和统计手册修订版。

更新日期:2018-05-07
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