There is increasing evidence that senescent cells are a driving force behind many age-related pathologies and that their selective elimination increases the life- and healthspan of mice. Senescent cells negatively affect their surrounding tissue by losing their cell specific functionality and by secreting a pro-tumorigenic and pro-inflammatory mixture of growth hormones, chemokines, cytokines and proteases, termed the senescence-associated secretory phenotype (SASP). Here we identified an extract from the plant Solidago virgaurea subsp. alpestris, which exhibited weak senolytic activity, delayed the acquisition of a senescent phenotype and induced a papillary phenotype with improved functionality in human dermal fibroblasts. When administered to stress-induced premature senescent fibroblasts, this extract changed their global mRNA expression profile and particularly reduced the expression of various SASP components, thereby ameliorating the negative influence on nearby cells. Thus, the investigated plant extract represents a promising possibility to block age-related loss of tissue functionality.

越来越多的证据表明，衰老细胞是许多与年龄相关的病理背后的驱动力，并且选择性消除它们可以延长小鼠的寿命和健康寿命。衰老细胞通过失去细胞特异性功能以及分泌生长激素、趋化因子、细胞因子和蛋白酶的促肿瘤和促炎混合物（称为衰老相关分泌表型（SASP））对周围组织产生负面影响。在这里，我们鉴定了来自植物一枝黄花亚种的提取物。alpestri表现出弱的衰老活性，延迟了衰老表型的获得，并诱导了人真皮成纤维细胞功能改善的乳头状表型。当给予应激诱导的过早衰老成纤维细胞时，该提取物改变了它们的整体 mRNA 表达谱，特别是降低了各种 SASP 成分的表达，从而改善了对附近细胞的负面影响。因此，所研究的植物提取物代表了阻止与年龄相关的组织功能丧失的有希望的可能性。