Despite highly effective antibiotics and intensive care support, the mortality associated with pneumonia has not substantially decreased since the 1960s [1]. Hence, there remains a major requirement for improved treatment and preventative strategies, which will need new knowledge on the pathogenesis of pneumonia. Animal models have obvious high value when investigating the molecular mechanisms involved in pneumonia pathogenesis, but they are also directly relevant for clinically orientated research into new therapies and vaccines, complications of pneumonia, and identifying high risk groups. In this article we describe how research using animal models will be essential if we are to reduce the immense morbidity and mortality associated with pneumonia. Animal models can provide incredibly detailed data on pathogenesis and immunology of lung infections, and will be essential for the development of novel therapeutic/preventative strategies to reduce the morbidity and mortality caused by pneumonia http://bit.ly/2pdCzcH

中文翻译：

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动物模型真的能教会我们有关肺炎的知识吗？亲

尽管有高效的抗生素和重症监护支持，但自 1960 年代以来，与肺炎相关的死亡率并未大幅下降 [1]。因此，仍然需要改进治疗和预防策略，这将需要有关肺炎发病机制的新知识。动物模型在研究肺炎发病的分子机制时具有明显的高价值，但它们也与临床研究新疗法和疫苗、肺炎并发症和识别高危人群直接相关。在本文中，我们描述了如果我们要降低与肺炎相关的巨大发病率和死亡率，使用动物模型的研究将是多么重要。