In their 1987 community-acquired pneumonia (CAP) guidelines, the British Thoracic Society recommended amoxicillin with or without erythromycin (or tetracycline) in all admitted patients, with the coverage for Legionella being mandatory in seriously ill patients [1]. They also recommended intravenous flucloxacillin when Staphylococcus aureus was suspected and gentamicin or ceftazidime if a Gram-negative agent was suspected. This guideline, now more than 30 years old, also emphasised the need to identify critically ill patients based on objective physiological criteria so they could receive intensive care support, recommended obtaining culture specimens when possible and stated that antibiotics should be started immediately upon diagnosis. All of these 1987 recommendations were based on clinical studies on the aetiology of pneumonia, analysis of the predictors of outcome from pneumonia from clinical studies and a series of observational studies comparing outcomes of different antibiotic regimens in the prior three decades. Animal models of pneumonia are severely flawed and need to change if they are going to help us with new therapies http://bit.ly/2B1d7tD

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动物模型真的能教会我们有关肺炎的知识吗？骗局

在其 1987 年的社区获得性肺炎 (CAP) 指南中，英国胸科学会建议所有入院患者均使用阿莫西林联合或不联合红霉素（或四环素），对重病患者强制要求加入军团菌[1]。他们还推荐在怀疑金黄色葡萄球菌时静脉注射氟氯西林，如果怀疑革兰氏阴性菌则推荐使用庆大霉素或头孢他啶。这份已有 30 多年历史的指南还强调需要根据客观的生理标准来识别危重患者，以便他们接受重症监护支持，建议尽可能获取培养标本，并指出应在确诊后立即开始使用抗生素。所有这些 1987 年的建议都是基于对肺炎病因的临床研究，对临床研究和一系列观察性研究中肺炎结果的预测因子进行分析，这些研究比较了过去 30 年不同抗生素治疗方案的结果。肺炎动物模型存在严重缺陷，如果它们要帮助我们开发新疗法就需要改变 http://bit.ly/2B1d7tD