COPD is a major burden globally. According to the Global Burden of Disease study, COPD caused 3.2 million deaths in 2015, accounting for 5% of all deaths worldwide, making it the third leading cause of death in the world [1]. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) defines spirometrically confirmed COPD based on a forced expiratory volume during the first second (FEV1) to a forced vital capacity (FVC) ratio smaller than 0.7 [2]. The severity of airflow obstruction is further defined through GOLD severity grades based on the ratio of FEV1 to its predicted value, with GOLD 1, 2, 3 and 4 defined around cut-off points of 80%, 50%, and 30% [2]. Preserved ratio impaired spirometry (PRISm) is a prevalent, neglected condition whose prognosis is close to that of COPD http://bit.ly/2Oydvq1

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通过“PRISm”查看 COPD 频谱

COPD 是全球的主要负担。根据全球疾病负担研究，2015年COPD导致320万人死亡，占全球死亡总数的5%，成为全球第三大死因[1]。慢性阻塞性肺疾病全球倡议 (GOLD) 根据第一秒用力呼气量 (FEV1) 与用力肺活量 (FVC) 之比小于 0.7 来定义肺活量测定确诊的 COPD [2]。根据 FEV1 与其预测值的比率，通过 GOLD 严重程度等级进一步定义气流阻塞的严重程度，其中 GOLD 1、2、3 和 4 定义在 80%、50% 和 30% 的临界点附近 [2 ]。保留比率受损肺活量测定 (PRISm) 是一种普遍的、被忽视的疾病，其预后接近 COPD http://bit.ly/2Oydvq1