Limited data are available regarding the prognostic factors for patients with nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated the prognostic factors associated with long-term mortality in NTM-PD patients after adjusting for individual confounders, including aetiological organism and radiological form. A total of 1445 patients with treatment-naïve NTM-PD who were newly diagnosed between July 1997 and December 2013 were included. The aetiological organisms were as follows: Mycobacterium avium (n=655), M. intracellulare (n=487), M. abscessus (n=129) and M. massiliense (n=174). The factors associated with mortality in NTM-PD patients were analysed using a multivariable Cox model after adjusting for demographic, radiological and aetiological data. The overall 5-, 10- and 15-year cumulative mortality rates for the NTM-PD patients were 12.4%, 24.0% and 36.4%, respectively. On multivariable analysis, the following factors were significantly associated with mortality in NTM-PD patients: old age, male sex, low body mass index, chronic pulmonary aspergillosis, pulmonary or extrapulmonary malignancy, chronic heart or liver disease and erythrocyte sedimentation rate. The aetiological organism was also significantly associated with mortality: M. intracellulare had an adjusted hazard ratio (aHR) of 1.40, 95% CI 1.03–1.91; M. abscessus had an aHR of 2.19, 95% CI 1.36–3.51; and M. massiliense had an aHR of 0.99, 95% CI 0.61–1.64, compared to M. avium. Mortality was also significantly associated with the radiological form of NTM-PD for the cavitary nodular bronchiectatic form (aHR 1.70, 95% CI 1.12–2.59) and the fibrocavitary form (aHR 2.12, 95% CI 1.57–3.08), compared to the non-cavitary nodular bronchiectatic form. Long-term mortality in patients with NTM-PD was significantly associated with the aetiological NTM organism, cavitary disease and certain demographic characteristics. The long-term mortality of patients with nontuberculous mycobacterial pulmonary disease was significantly associated with the aetiological organism, cavitary disease and certain demographic characteristics http://bit.ly/2kyXTHT

中文翻译：

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1445 名非结核分枝杆菌肺病患者与长期死亡率相关的预后因素：一项为期 15 年的随访研究

关于非结核分枝杆菌肺病 (NTM-PD) 患者预后因素的数据有限。在调整个体混杂因素（包括病因生物和放射学形式）后，我们调查了与 NTM-PD 患者长期死亡率相关的预后因素。共纳入 1445 名 1997 年 7 月至 2013 年 12 月期间新诊断的初治 NTM-PD 患者。病原体如下：鸟分枝杆菌(n=655)、胞内分枝杆菌(n=487)、脓肿分枝杆菌(n=129)和马氏分枝杆菌(n=174)。在调整人口统计学、放射学和病因学数据后，使用多变量 Cox 模型分析与 NTM-PD 患者死亡率相关的因素。总体5-，NTM-PD 患者的 10 年和 15 年累积死亡率分别为 12.4%、24.0% 和 36.4%。在多变量分析中，以下因素与 NTM-PD 患者的死亡率显着相关：高龄、男性、低体重指数、慢性肺曲霉病、肺或肺外恶性肿瘤、慢性心脏或肝脏疾病和红细胞沉降率。病原微生物也与死亡率显着相关：胞内分枝杆菌的调整风险比 (aHR) 为 1.40，95% CI 1.03–1.91；脓肿分枝杆菌的 aHR 为 2.19，95% CI 1.36–3.51；与 M. massiliense 相比，M. massiliense 的 aHR 为 0.99，95% CI 0.61–1.64。对于空洞结节性支气管扩张形式，死亡率也与 NTM-PD 的放射学形式显着相关（aHR 1.70，95% CI 1.12-2。59) 和纤维空洞形式 (aHR 2.12, 95% CI 1.57–3.08)，与非空洞结节性支气管扩张形式相比。NTM-PD 患者的长期死亡率与 NTM 病原体、空洞疾病和某些人口统计学特征显着相关。非结核分枝杆菌肺病患者的长期死亡率与病原微生物、空洞病和某些人口统计学特征显着相关 http://bit.ly/2kyXTHT