Anti-Infective Application of Graphene-Like Silicon Nanosheets via Membrane Destruction.,Advanced Healthcare Materials

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Anti-Infective Application of Graphene-Like Silicon Nanosheets via Membrane Destruction.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-01-01 , DOI: 10.1002/adhm.201901375
Yao Luo ₁ , Min Ge _{2,

3} , Han Lin _{2,

3} , Renke He ₁ , Xiangwei Yuan ₁ , Chao Yang ₁ , Wei Wang ₁ , Xianlong Zhang ₁

Affiliation

The increasing problem of bacterial resistance to the currently effective antibiotics has resulted in the need for increasingly potent therapeutics to eradicate pathogenic microorganisms. 2D nanomaterials (2D NMs) have unique physical and chemical properties that make them attractive candidates for biomedical applications. Recently, the application of 2D NMs as antibacterial agents has attracted significant attention. Herein, a novel 2D graphene-like silicon nanosheet (GS NS) antimicrobial agent is fabricated from pristine silicon crystals by ultrasonication, which results in a highly exfoliated planar morphology and a significantly larger surface area as compared with bulk silicon. The GS NSs exhibit remarkable in vitro broad-spectrum bactericidal activity against Gram (-) Escherichia coli and Gram (+) Staphylococcus aureus because of a close interaction with the bacteria, which leads to highly efficient membrane destruction. The in vivo studies demonstrate that the local administration of GS NSs effectively mitigates implant-related infection by reducing the bacterial burden of the extracted samples and accelerating the remission of local inflammation. Based on these encouraging results, GS NSs are expected to be a useful new member of the 2D NMs family, with the potential of effectively killing pathogenic bacteria in clinical applications.

中文翻译：

类似于石墨烯的硅纳米片通过膜破坏的抗感染应用。

细菌对当前有效的抗生素的抗药性的日益增加的问题导致了对消灭病原微生物的日益有效的治疗的需要。2D纳米材料（2D NMs）具有独特的物理和化学特性，使其成为生物医学应用的有吸引力的候选材料。近来，二维NMs作为抗菌剂的应用引起了广泛的关注。在此，通过超声处理由原始硅晶体制造新颖的二维石墨烯样硅纳米片（GS NS）抗菌剂，与块状硅相比，其导致高度剥落的平面形态和显着更大的表面积。由于与细菌的紧密相互作用，GS NSs对革兰氏阳性大肠杆菌和金黄色葡萄球菌具有显着的体外广谱杀菌活性，从而导致高效的膜破坏。体内研究表明，GS NSs的局部给药可通过减少提取样品的细菌负担并加速局部炎症的缓解来有效减轻植入物相关的感染。基于这些令人鼓舞的结果，预计GS NS将成为2D NMs系列的有用新成员，并具有在临床应用中有效杀死病原细菌的潜力。体内研究表明，GS NSs的局部给药可通过减少提取样品的细菌负担并加速局部炎症的缓解来有效减轻植入物相关的感染。基于这些令人鼓舞的结果，预计GS NSs将成为2D NMs系列的有用新成员，并具有在临床应用中有效杀死病原细菌的潜力。体内研究表明，GS NSs的局部给药可通过减少提取样品的细菌负担并加速局部炎症的缓解来有效减轻植入物相关的感染。基于这些令人鼓舞的结果，预计GS NSs将成为2D NMs系列的有用新成员，并具有在临床应用中有效杀死病原细菌的潜力。

更新日期：2020-02-06

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