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One-year all-cause mortality risk among atrial fibrillation patients in Middle East with and without diabetes: The Gulf SAFE registry.
International Journal of Cardiology ( IF 3.2 ) Pub Date : 2020-01-02 , DOI: 10.1016/j.ijcard.2019.12.061
Magdalena Domek 1 , Yan-Guang Li 2 , Jakub Gumprecht 3 , Nidal Asaad 4 , Wafa Rashed 5 , Alawi Alsheikh-Ali 6 , Katarzyna Nabrdalik 7 , Janusz Gumprecht 7 , Mohammad Zubaid 8 , Gregory Y H Lip 9
Affiliation  

BACKGROUND Atrial fibrillation (AF) poses a great risk of mortality, especially when associated with diabetes mellitus (DM). OBJECTIVES We aimed to investigate the rate and risk factors for mortality among AF patients with and without DM in the population from the Middle East where it has never been investigated before. METHODS We analyzed the Gulf-SAFE registry, involving patients with nonvalvular AF from the Middle East, for one-year all-cause mortality. The predictive capability of the CHA2DS2-VASc score for death was also investigated. RESULTS Among a total of 2043 AF patients 606 had DM. Patients with DM were older and had significantly higher prevalence of multiple comorbidities (p < 0.05, respectively). Among patients with DM, age ≥ 75 (relative risk 2.34, 95% confidence interval 1.19-4.61), heart failure (HF) (RR 2.14, 95%CI 1.03-4.43), peripheral vascular disease (PVD) (RR 3.36, 95%CI 1.22-9.30) and chronic kidney disease (CKD) (RR 2.60, 95%CI 1.16-5.81) were independent risk factors for one year all-cause mortality. Patients with DM had significantly higher rates of heart failure and AF-related hospital admissions, all-cause mortality and composite outcome rates, in one year follow up. Among patients with DM, the CHA2DS2-VASc score was predictive of one-year all-cause mortality with c-index of 0.741 (95%CI 0.688-0.794). CONCLUSIONS AF patients in Middle East with DM have a higher risk for all-cause mortality, HF and AF admission and composite outcome, compared to patients without DM. Multiple risk factors contribute to the higher mortality rate among patients with DM.

中文翻译:

患有和不患有糖尿病的中东房颤患者一年全因死亡风险:海湾SAFE注册表。

背景技术房颤(AF)带来很大的死亡风险,尤其是与糖尿病(DM)相关时。目的我们旨在调查从未有过调查的中东人群中,患有或不患有糖尿病的房颤患者的死亡率和危险因素。方法我们分析了来自中东非瓣膜性房颤患者的Gulf-SAFE登记册的一年全因死亡率。还研究了CHA2DS2-VASc评分对死亡的预测能力。结果在总共2043名AF患者中,有606名患有DM。DM患者年龄较大,多种合并症的患病率明显更高(分别为p <0.05)。在DM患者中,年龄≥75(相对风险2.34,95%置信区间1.19-4.61),心力衰竭(HF)(RR 2.14,95%CI 1.03-4。43),周围血管疾病(PVD)(RR 3.36,95%CI 1.22-9.30)和慢性肾脏病(CKD)(RR 2.60,95%CI 1.16-5.81)是一年全因死亡率的独立危险因素。在一年的随访中,DM患者的心衰和心房颤动相关的住院率,全因死亡率和综合结局发生率明显更高。在DM患者中,CHA2DS2-VASc评分可预测一年全因死亡率,c-指数为0.741(95%CI 0.688-0.794)。结论与没有DM的患者相比,中东有DM的AF患者的全因死亡率,HF和AF入院及综合结局的风险更高。多种危险因素导致DM患者较高的死亡率。95%CI 1.16-5.81)是一年全因死亡率的独立危险因素。在一年的随访中,DM患者的心衰和心房颤动相关的住院率,全因死亡率和综合结局发生率明显更高。在DM患者中,CHA2DS2-VASc评分可预测一年全因死亡率,c-指数为0.741(95%CI 0.688-0.794)。结论与没有DM的患者相比,中东有DM的AF患者的全因死亡率,HF和AF入院及综合结局的风险更高。多种危险因素导致DM患者较高的死亡率。95%CI 1.16-5.81)是一年全因死亡率的独立危险因素。在一年的随访中,DM患者的心衰和心房颤动相关的住院率,全因死亡率和综合结局发生率明显更高。在DM患者中,CHA2DS2-VASc评分可预测一年全因死亡率,c-指数为0.741(95%CI 0.688-0.794)。结论与没有DM的患者相比,中东有DM的AF患者的全因死亡率,HF和AF入院及综合结局的风险更高。多种危险因素导致DM患者较高的死亡率。一年随访中的全因死亡率和综合结局率。在DM患者中,CHA2DS2-VASc评分可预测一年全因死亡率,c-指数为0.741(95%CI 0.688-0.794)。结论与没有DM的患者相比,中东有DM的AF患者的全因死亡率,HF和AF入院及综合结局的风险更高。多种危险因素导致DM患者较高的死亡率。一年随访中的全因死亡率和综合结局率。在DM患者中,CHA2DS2-VASc评分可预测一年全因死亡率,c-指数为0.741(95%CI 0.688-0.794)。结论与没有DM的患者相比,中东有DM的AF患者的全因死亡率,HF和AF入院及综合结局的风险更高。多种危险因素导致DM患者较高的死亡率。
更新日期:2020-01-02
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