Triple negative breast cancer (TNBC) is a breast cancer subtype which is particularly aggressive and invasive. The treatment of TNBC has been limited due to the lack of well-defined molecular targets. Exosomes are nano-sized extracellular vesicles that are released from virtually all cell types into the extracellular space. Due to their endocytic origin, exosomes carry valuable information from their cells of origin. Exosomes were first thought to serve as "garbage disposals" that eliminate unwanted cellular components. Later, they were found to be involved in the pathology of many diseases including cancer. Despite their established roles in multiple diseases, only a small number of studies have focused on the role of exosomes in TNBC. In this review, we outline the roles of exosomes in cancer progression, metastasis and drug resistance in this breast cancer subtype. We then further illustrate the potential roles of exosomes as diagnostic tools, therapeutic targets and delivery systems.

中文翻译：

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三重阴性乳腺癌中的外泌体：垃圾处理或特洛伊木马？

三阴性乳腺癌（TNBC）是一种特别具有侵略性和侵袭性的乳腺癌亚型。由于缺乏明确的分子靶标，TNBC的治疗受到了限制。外来体是从几乎所有细胞类型释放到细胞外空间的纳米级细胞外囊泡。由于其内吞起源，外来体从其起源细胞携带有价值的信息。外来体最初被认为是消除垃圾细胞成分的“垃圾处理”。后来，他们被发现参与包括癌症在内的许多疾病的病理学研究。尽管它们在多种疾病中起着确定的作用，但只有少数研究集中在外来体在TNBC中的作用。在这篇评论中，我们概述了外泌体在癌症进展中的作用，这种乳腺癌亚型的转移和耐药性。然后，我们进一步说明了外泌体作为诊断工具，治疗靶标和递送系统的潜在作用。