Nanotechnology-based therapeutic approaches have attracted attention of scientists, in particular due to the special features of nanomaterials, such as adequate biocompatibility, ability to improve therapeutic efficiency of incorporated drugs and to limit their adverse effects. Among a variety of reported nanomaterials for biomedical applications, metal and metal oxide-based nanoparticles offer unique physicochemical properties allowing their use in combination with conventional antimicrobials and as magnetic field-controlled drug delivery nanocarriers. An ever-growing number of studies demonstrate that by combining magnetic nanoparticles with membrane-active, natural human cathelicidin-derived LL-37 peptide, and its synthetic mimics such as ceragenins, innovative nanoagents might be developed. Between others, they demonstrate high clinical potential as antimicrobial, anti-cancer, immunomodulatory and regenerative agents. Due to continuous research, knowledge on pleiotropic character of natural antibacterial peptides and their mimics is growing, and it is justifying to stay that the therapeutic potential of nanosystems containing membrane active compounds has not been exhausted yet.

中文翻译：

---

纳米抗菌素含有附着在磁性纳米粒子表面的具有膜活性的人cathelicidin LL-37或合成的骨瓷皂素，是一种新颖和创新的治疗工具：当前状态和潜在的未来应用。

基于纳米技术的治疗方法引起了科学家的注意，特别是由于纳米材料的特殊功能，例如足够的生物相容性，提高掺入药物的治疗效率并限制其不良反应的能力。在各种已报道的用于生物医学应用的纳米材料中，金属和基于金属氧化物的纳米颗粒具有独特的物理化学特性，使其可以与常规抗菌剂结合使用，并作为磁场控制的药物输送纳米载体使用。越来越多的研究表明，通过将磁性纳米粒子与具有膜活性的天然人Cathelicidin衍生的LL-37肽及其合成模拟物（如陶瓷素）结合使用，可以开发出创新的纳米剂。彼此之间 它们具有作为抗菌剂，抗癌剂，免疫调节剂和再生剂的巨大临床潜力。由于不断的研究，关于天然抗菌肽及其模拟物的多效性的知识正在增长，并且有理由断言，包含膜活性化合物的纳米系统的治疗潜力尚未耗尽。