OBJECTIVES To develop separate item banks for three health domains of health-related quality of life (HRQOL) ranked as important by Singaporeans - physical functioning, social relationships, and positive mindset. METHODS We adapted the Patient Reported Outcomes Measurement Information System Qualitative Item Review protocol, with input and endorsement from laymen and experts from various relevant fields. Items were generated from 3 sources: 1) thematic analysis of focus groups and in-depth interviews for framework (n = 134 participants) and item(n = 52 participants) development, 2) instruments identified from a literature search (PubMed) of studies that developed or validated a HRQOL instrument among adults in Singapore, 3) a priori identified instruments of particular relevance. Items from these three sources were "binned" and "winnowed" by two independent reviewers, blinded to the source of the items, who harmonized their selections to generate a list of candidate items (each item representing a subdomain). Panels with lay and expert representation, convened separately for each domain, reviewed the face and content validity of these candidate items and provided inputs for item revision. The revised items were further refined in cognitive interviews. RESULTS Items from our qualitative studies (51 physical functioning, 44 social relationships, and 38 positive mindset), the literature review (36 instruments from 161 citations), and three a priori identified instruments, underwent binning, winnowing, expert panel review, and cognitive interview. This resulted in 160 candidate items (61 physical functioning, 51 social relationships, and 48 positive mindset). CONCLUSIONS We developed item banks for three important health domains in Singapore using inputs from potential end-users and the published literature. The next steps are to calibrate the item banks, develop computerized adaptive tests (CATs) using the calibrated items, and evaluate the validity of test scores when these item banks are administered adaptively.

中文翻译：

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开发项目银行以衡量新加坡与健康相关的生活质量（HRQOL）的三个重要领域。

目的针对与健康相关的生活质量（HRQOL）的三个健康领域（新加坡人认为最重要）开发单独的项目库-身体机能，社会关系和积极的心态。方法我们采用了患者报告的结果测量信息系统定性项目审查方案，并得到了来自各相关领域的外行和专家的意见和支持。项目来自3个来源：1）焦点小组的主题分析和对框架的深入访谈（n = 134名参与者）和项目（n = 52名参与者），2）从文献检索（PubMed）研究中确定的工具在新加坡成年人中开发或验证了HRQOL仪器的方法； 3）先验确定的具有特殊意义的仪器。这三个来源的项目分别是“分类”和“ 结论我们利用潜在最终用户的输入和已发表的文献为新加坡的三个重要卫生领域开发了项目库。下一步是校准项目库，使用已校准的项目开发计算机化的自适应测试（CAT），并在自适应管理这些项目库时评估测试成绩的有效性。